The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weiser, W. Y.
Right arrow Articles by David, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weiser, W. Y.
Right arrow Articles by David, J. R.

The Journal of Immunology, Vol 147, Issue 6 2006-2011, Copyright © 1991 by American Association of Immunologists

ARTICLES

Human recombinant migration inhibitory factor activates human macrophages to kill Leishmania donovani [published erratum appears in J Immunol 1993 Nov 1;151(9):following 5105]

WY Weiser, LM Pozzi and JR David
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115.

A recombinant form of the first lymphokine to be discovered, migration inhibitory factor (rMIF) was obtained from COS-1 cells transfected with a cDNA library from a human T cell hybridoma (6). rMIF has an amino acid sequence unrelated to that of any known protein. To learn more about the biology of MIF, we tested its ability to effect the survival of Leishmania donovani in macrophages. We found that rMIF activates blood monocyte-derived macrophages in vitro to suppress the growth of and kill these intracellular parasites. The anti-leishmanial effect (ranging from 50 to 77% reduction of parasites) is maximal when macrophages have been incubated with rMIF 48 to 72 h before infection and is similar to that seen with macrophages activated by IFN-gamma. Of interest, whereas the activation of human macrophages by IFN-gamma is inhibited by IL-4 and not enhanced by LPS, the activation by rMIF is enhanced by LPS but is not inhibited by IL-4. The data presented here demonstrate that rMIF is a potent activator of macrophages and is likely to be critical in cell-mediated immune host defenses.


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. Matsuda, J. Nishihira, Y. Takahashi, O. Kemmotsu, and Y. Hattori
Role of Macrophage Migration Inhibitory Factor in Acute Lung Injury in Mice with Acute Pancreatitis Complicated by Endotoxemia
Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 198 - 205.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
F. Arcuri, C. Ricci, F. Ietta, M. Cintorino, S. A. Tripodi, I. Cetin, E. Garzia, F. Schatz, P. Klemi, R. Santopietro, et al.
Macrophage Migration Inhibitory Factor in the Human Endometrium: Expression and Localization During the Menstrual Cycle and Early Pregnancy
Biol Reprod, April 1, 2001; 64(4): 1200 - 1205.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
S.-i. Wada, T. Kudo, M. Kudo, N. Sakuragi, H. Hareyama, J. Nishihira, and S. Fujimoto
Induction of macrophage migration inhibitory factor in human ovary by human chorionic gonadotrophin
Hum. Reprod., February 1, 1999; 14(2): 395 - 399.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.