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The Journal of Immunology, Vol 147, Issue 5 1537-1541, Copyright © 1991 by American Association of Immunologists

ARTICLES

Histologic analysis of T lymphocyte activation in reactive lymph nodes

SA Bogen, DS Weinberg and AK Abbas
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

As an approach to defining the anatomic sites of T cell activation in situ, we have developed an immunocytochemical stain for IL-2, a T cell- derived cytokine synthesized shortly after Ag-induced activation. Analysis of lymph nodes from mice immunized with keyhole limpet hemocyanin emulsified in CFA demonstrates that the IL2+ cells appear in a perivascular location 4 days after antigenic challenge. After germinal centers develop, IL-2+ cells are situated in a parafollicular pattern. Serial sections stained for different types of APC, including B cells, interdigitating dendritic cells, and macrophages, demonstrate a close physical association between IL-2+ cells and macrophages. These findings may have important implications for defining how APC bearing processed Ag and Ag-specific T cells interact in the complex environment of lymphoid tissues.


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