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The Journal of Immunology, Vol 147, Issue 4 1201-1207, Copyright © 1991 by American Association of Immunologists
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JK Lazdins, T Klimkait, K Woods-Cook, M Walker, E Alteri, D Cox, N Cerletti, R Shipman, G Bilbe and G McMaster
CIBA-GEIGY Ltd., Pharma Research, Basel, Switzerland.
In vitro-differentiated monocytes can be infected with the monocytotropic isolate of HIV-1/ADA. The infection is characterized by formation of giant cells and production of virus that can be found in cell supernatants or cell-associated. In this study, we demonstrate that the above described parameters of infection can be enhanced by a factor present in acidified M phi supernatants, suggesting that it might be transforming growth factor beta-1 (TGF-beta 1). When recombinant or purified TGF-beta were examined, similar activities were detected. This effect apparently is not because of changes in the cellular phenotype that could favor infection. The effect of TGF-beta is exerted on cells once infection is established or on cells with active virus production. The activity can be also demonstrated using U- 937 cells.
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