The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fiorentino, D. F.
Right arrow Articles by O'Garra, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fiorentino, D. F.
Right arrow Articles by O'Garra, A.

The Journal of Immunology, Vol 147, Issue 11 3815-3822, Copyright © 1991 by American Association of Immunologists

ARTICLES

IL-10 inhibits cytokine production by activated macrophages

DF Fiorentino, A Zlotnik, TR Mosmann, M Howard and A O'Garra
DNAX Research Institute, Palo Alto, CA 94304.

IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by Th1 T cell clones. In this study we have examined the direct effects of IL-10 on both macrophage cell lines and normal peritoneal macrophages. LPS (or LPS and IFN-gamma)-induced production of IL-1, IL-6, and TNF-alpha proteins was significantly inhibited by IL-10 in two macrophage cell lines. Furthermore, IL-10 appears to be a more potent inhibitor of monokine synthesis than IL-4 when added at similar concentrations. LPS or LPS- and IFN-gamma-induced expression of IL-1 alpha, IL-6, or TNF-alpha mRNA was also inhibited by IL-10 as shown by semiquantitative polymerase chain reaction or Northern blot analysis. Inhibition of LPS-induced IL-6 secretion by IL- 10 was less marked in FACS-purified peritoneal macrophages than in the macrophage cell lines. However, IL-6 production by peritoneal macrophages was enhanced by addition of anti-IL-10 antibodies, implying the presence in these cultures of endogenous IL-10, which results in an intrinsic reduction of monokine synthesis after LPS activation. Consistent with this proposal, LPS-stimulated peritoneal macrophages were shown to directly produce IL-10 detectable by ELISA. Furthermore, IFN-gamma was found to enhance IL-6 production by LPS-stimulated peritoneal macrophages, and this could be explained by its suppression of IL-10 production by this same population of cells. In addition to its effects on monokine synthesis, IL-10 also induces a significant change in morphology in IFN-gamma-stimulated peritoneal macrophages. The potent action of IL-10 on the macrophage, particularly at the level of monokine production, supports an important role for this cytokine not only in the regulation of T cell responses but also in acute inflammatory responses.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. El-behi, B. Ciric, S. Yu, G.-X. Zhang, D. C. Fitzgerald, and A. Rostami
Differential Effect of IL-27 on Developing versus Committed Th17 Cells
J. Immunol., October 15, 2009; 183(8): 4957 - 4967.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Slobedman, P. A. Barry, J. V. Spencer, S. Avdic, and A. Abendroth
Virus-Encoded Homologs of Cellular Interleukin-10 and Their Control of Host Immune Function
J. Virol., October 1, 2009; 83(19): 9618 - 9629.
[Full Text] [PDF]

Home page
 JEMHome page
F. Kaiser, D. Cook, S. Papoutsopoulou, R. Rajsbaum, X. Wu, H.-T. Yang, S. Grant, P. Ricciardi-Castagnoli, P. N. Tsichlis, S. C. Ley, et al.
TPL-2 negatively regulates interferon-{beta} production in macrophages and myeloid dendritic cells
J. Exp. Med., August 31, 2009; 206(9): 1863 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. E. Troy, C. Zaph, Y. Du, B. C. Taylor, K. J. Guild, C. A. Hunter, C. J. M. Saris, and D. Artis
IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis
J. Immunol., August 1, 2009; 183(3): 2037 - 2044.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Metenou, B. Dembele, S. Konate, H. Dolo, S. Y. Coulibaly, Y. I. Coulibaly, A. A. Diallo, L. Soumaoro, M. E. Coulibaly, D. Sanogo, et al.
Patent Filarial Infection Modulates Malaria-Specific Type 1 Cytokine Responses in an IL-10-Dependent Manner in a Filaria/Malaria-Coinfected Population
J. Immunol., July 15, 2009; 183(2): 916 - 924.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Day, A. Friedman, and L. S. Schlesinger
Modeling the immune rheostat of macrophages in the lung in response to infection
PNAS, July 7, 2009; 106(27): 11246 - 11251.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
I. Lakhal-Naouar, T. Boussoffara, A. Meddeb-Garnaoui, Y. Ben Achour-Chenik, H. Louzir, and M. Chenik
Cellular and Humoral Responses to Leishmania major Virulence Factors in Healed Cutaneous Leishmaniasis and Mediterranean Visceral Leishmaniasis Patients
Clin. Vaccine Immunol., June 1, 2009; 16(6): 956 - 958.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
V. Varma, A. Yao-Borengasser, N. Rasouli, G. T. Nolen, B. Phanavanh, T. Starks, C. Gurley, P. Simpson, R. E. McGehee Jr., P. A. Kern, et al.
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action
Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1300 - E1310.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
E. Cochery-Nouvellon, P. Nguyen, R. Attaoua, P. Cornillet-Lefebvre, E. Mercier, F. Vitry, and J.-C. Gris
Interleukin 10 Gene Promoter Polymorphisms in Women with Pregnancy Loss: Preferential Association with Embryonic Wastage
Biol Reprod, June 1, 2009; 80(6): 1115 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Xu, Y. Yang, G. Qiu, G. Lal, Z. Wu, D. E. Levy, J. C. Ochando, J. S. Bromberg, and Y. Ding
c-Maf Regulates IL-10 Expression during Th17 Polarization
J. Immunol., May 15, 2009; 182(10): 6226 - 6236.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
A. Kajikawa and S. Igimi
Reduction of Tumor Necrosis Factor Alpha-Inducing Capacity of Recombinant Lactobacillus casei via Expression of Salmonella OmpC
Appl. Envir. Microbiol., May 1, 2009; 75(9): 2727 - 2734.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. P. McAleer, R. J. Rossi, and A. T. Vella
Lipopolysaccharide Potentiates Effector T Cell Accumulation into Nonlymphoid Tissues through TRIF
J. Immunol., May 1, 2009; 182(9): 5322 - 5330.
[Abstract] [Full Text] [PDF]

Home page
 DNA ResHome page
M. Hattori and T. D. Taylor
The Human Intestinal Microbiome: A New Frontier of Human Biology
DNA Res, February 1, 2009; 16(1): 1 - 12.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
V. Samokhvalov, P. J. Bilan, J. D. Schertzer, C. N. Antonescu, and A. Klip
Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells
Am J Physiol Endocrinol Metab, January 1, 2009; 296(1): E37 - E46.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. R. Brown, A. Y.-C. Lai, S. T. Callen, V. A. Blaho, J. M. Hughes, and W. J. Mitchell
Adenoviral Delivery of Interleukin-10 Fails To Attenuate Experimental Lyme Disease
Infect. Immun., December 1, 2008; 76(12): 5500 - 5507.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. M. Ngoi, M. G. Tovey, and A. T. Vella
Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-{alpha}/{beta}
J. Immunol., December 1, 2008; 181(11): 7670 - 7680.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. D. Tachado, X. Li, K. Swan, N. Patel, and H. Koziel
Constitutive Activation of Phosphatidylinositol 3-Kinase Signaling Pathway Down-regulates TLR4-mediated Tumor Necrosis Factor-{alpha} Release in Alveolar Macrophages from Asymptomatic HIV-positive Persons in Vitro
J. Biol. Chem., November 28, 2008; 283(48): 33191 - 33198.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. L. Beamer, D. K. Flaherty, B. D. Assogba, P. Stromberg, M. Gonzalez-Juarrero, R. de Waal Malefyt, B. Vesosky, and J. Turner
Interleukin-10 Promotes Mycobacterium tuberculosis Disease Progression in CBA/J Mice
J. Immunol., October 15, 2008; 181(8): 5545 - 5550.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. d. l. C. Dominguez-Punaro, M. Segura, D. Radzioch, S. Rivest, and M. Gottschalk
Comparison of the Susceptibilities of C57BL/6 and A/J Mouse Strains to Streptococcus suis Serotype 2 Infection
Infect. Immun., September 1, 2008; 76(9): 3901 - 3910.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
T. Li, B. Zhao, C. Wang, H. Wang, Z. Liu, W. Li, H. Jin, C. Tang, and J. Du
Regulatory Effects of Hydrogen Sulfide on IL-6, IL-8 and IL-10 Levels in the Plasma and Pulmonary Tissue of Rats with Acute Lung Injury
Experimental Biology and Medicine, September 1, 2008; 233(9): 1081 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. J. Toltl, S. Beaudin, P. C. Liaw, and and the Canadian Critical Care Translational Biolo
Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes
J. Immunol., August 1, 2008; 181(3): 2165 - 2173.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
A Malarstig, P Eriksson, A Hamsten, B Lindahl, L Wallentin, and A Siegbahn
Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome
Heart, June 1, 2008; 94(6): 724 - 729.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Fang, G. C. Sharp, and H. Braley-Mullen
Interleukin-10 Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis
Am. J. Pathol., June 1, 2008; 172(6): 1591 - 1602.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
P.-h. Park, H. Huang, M. R. McMullen, K. Bryan, and L. E. Nagy
Activation of cyclic-AMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expression in raw 264.7 macrophages
J. Leukoc. Biol., May 1, 2008; 83(5): 1258 - 1266.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Salhi, V. Rodrigues Jr., F. Santoro, H. Dessein, A. Romano, L. R. Castellano, M. Sertorio, S. Rafati, C. Chevillard, A. Prata, et al.
Immunological and Genetic Evidence for a Crucial Role of IL-10 in Cutaneous Lesions in Humans Infected with Leishmania braziliensis
J. Immunol., May 1, 2008; 180(9): 6139 - 6148.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. K. Agarwal, R. Horai, A. M. Viley, P. B. Silver, R. S. Grajewski, S. Bo Su, A. T. Yazdani, W. Zhu, M. Kronenberg, P. J. Murray, et al.
Abrogation of Anti-Retinal Autoimmunity in IL-10 Transgenic Mice Due to Reduced T Cell Priming and Inhibition of Disease Effector Mechanisms
J. Immunol., April 15, 2008; 180(8): 5423 - 5429.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Souza, M. S. P. Azevedo, K. Jung, S. Cheetham, and L. J. Saif
Pathogenesis and Immune Responses in Gnotobiotic Calves after Infection with the Genogroup II.4-HS66 Strain of Human Norovirus
J. Virol., February 15, 2008; 82(4): 1777 - 1786.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. McFarlane, C. Perez, M. Charmoy, C. Allenbach, K. C. Carter, J. Alexander, and F. Tacchini-Cottier
Neutrophils Contribute to Development of a Protective Immune Response during Onset of Infection with Leishmania donovani
Infect. Immun., February 1, 2008; 76(2): 532 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Girndt, P. Stenvinkel, C. Ulrich, J. Axelsson, L. Nordfors, P. Barany, J. J. Carrero, G. H. Heine, H. Kaul, and H. Kohler
Influence of cytokine gene polymorphisms on erythropoetin dose requirements in chronic haemodialysis patients
Nephrol. Dial. Transplant., December 1, 2007; 22(12): 3586 - 3592.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Zeni, L. Mazzetti, D. Miotto, N. Lo Cascio, P. Maestrelli, P. Querzoli, M. Pedriali, E. De Rosa, L. M. Fabbri, C. E. Mapp, et al.
Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer
Eur. Respir. J., October 1, 2007; 30(4): 627 - 632.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. S. Biswas, V. Pedicord, A. Ploss, E. Menet, I. Leiner, and E. G. Pamer
Pathogen-Specific CD8 T Cell Responses Are Directly Inhibited by IL-10
J. Immunol., October 1, 2007; 179(7): 4520 - 4528.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Souza, S. M. Cheetham, M. S. P. Azevedo, V. Costantini, and L. J. Saif
Cytokine and Antibody Responses in Gnotobiotic Pigs after Infection with Human Norovirus Genogroup II.4 (HS66 Strain)
J. Virol., September 1, 2007; 81(17): 9183 - 9192.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J.-E. Ghia, P. Blennerhassett, and S. M. Collins
Vagus nerve integrity and experimental colitis
Am J Physiol Gastrointest Liver Physiol, September 1, 2007; 293(3): G560 - G567.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Koga, I. Kuwahara, E. P. Lillehoj, W. Lu, T. Miyata, Y. Isohama, and K. C. Kim
TNF-{alpha} induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implication
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L693 - L701.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Shrestha, C. Wang, B. Aissani, C. M. Wilson, J. Tang, and R. A. Kaslow
Interleukin-10 Gene (IL10) Polymorphisms and Human Papillomavirus Clearance among Immunosuppressed Adolescents
Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1626 - 1632.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
C.-H. Hsing, C.-C. Hsu, W.-Y. Chen, L.-Y. Chang, J.-C. Hwang, and M.-S. Chang
Expression of IL-19 correlates with Th2 cytokines in uraemic patients
Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2230 - 2238.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Chelvarajan, D. Popa, Y. Liu, T. V. Getchell, A. J. Stromberg, and S. Bondada
Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages
J. Leukoc. Biol., August 1, 2007; 82(2): 403 - 416.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
T. Islam, W. J. Gauderman, W. Cozen, and T. M. Mack
Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins
Neurology, July 24, 2007; 69(4): 381 - 388.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Barrett, C. Dai, J. Gamberg, M. Gallant, and M. Grant
Circulating CD14-CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10
J. Leukoc. Biol., July 1, 2007; 82(1): 152 - 160.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. A. Laborde, S. Vanzulli, M. Beigier-Bompadre, M. A. Isturiz, R. A. Ruggiero, M. G. Fourcade, A. C. Catalan Pellet, S. Sozzani, and M. Vulcano
Immune Complexes Inhibit Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells
J. Immunol., July 1, 2007; 179(1): 673 - 681.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
Y. Houri-Haddad, W.A. Soskolne, A. Halabi, and L. Shapira
IL-10 Gene Transfer Attenuates P. gingivalis-induced Inflammation
Journal of Dental Research, June 1, 2007; 86(6): 560 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
M. N Bittar, N. H Khasati, A. K Deiraniya, and N. Yonan
Interleukin-4 C-590T Polymorphism Has No Role in Coronary Artery Bypass Surgery
Asian Cardiovasc Thorac Ann, June 1, 2007; 15(3): 214 - 217.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Y. Chang, B. Guo, S. E. Doyle, and G. Cheng
Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production
J. Immunol., June 1, 2007; 178(11): 6705 - 6709.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Yanagawa and K. Onoe
Enhanced IL-10 Production by TLR4- and TLR2-Primed Dendritic Cells upon TLR Restimulation
J. Immunol., May 15, 2007; 178(10): 6173 - 6180.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. M. Ripoll, K. M. Irvine, T. Ravasi, M. J. Sweet, and D. A. Hume
Gpnmb Is Induced in Macrophages by IFN-{gamma} and Lipopolysaccharide and Acts as a Feedback Regulator of Proinflammatory Responses
J. Immunol., May 15, 2007; 178(10): 6557 - 6566.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P. Zymek, D.-Y. Nah, M. Bujak, G. Ren, A. Koerting, T. Leucker, P. Huebener, G. Taffet, M. Entman, and N. G. Frangogiannis
Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling
Cardiovasc Res, May 1, 2007; 74(2): 313 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Divangahi, A. Demoule, G. Danialou, L. Yahiaoui, W. Bao, Z. Xing, and B. J. Petrof
Impact of IL-10 on Diaphragmatic Cytokine Expression and Contractility during Pseudomonas Infection
Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 504 - 512.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Nakayama, D. M. Underhill, T. W. Petersen, B. Li, T. Kitamura, T. Takai, and A. Aderem
Paired Ig-Like Receptors Bind to Bacteria and Shape TLR-Mediated Cytokine Production
J. Immunol., April 1, 2007; 178(7): 4250 - 4259.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
D. Jankovic, M. C. Kullberg, C. G. Feng, R. S. Goldszmid, C. M. Collazo, M. Wilson, T. A. Wynn, M. Kamanaka, R. A. Flavell, and A. Sher
Conventional T-bet+Foxp3- Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
J. Exp. Med., February 19, 2007; 204(2): 273 - 283.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. R. Flores, K. A. Diggs, L. M. Tait, and P. A. Morel
IFN-{gamma} Negatively Regulates CpG-Induced IL-10 in Bone Marrow-Derived Dendritic Cells
J. Immunol., January 1, 2007; 178(1): 211 - 218.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. A. Eming, S. Werner, P. Bugnon, C. Wickenhauser, L. Siewe, O. Utermohlen, J. M. Davidson, T. Krieg, and A. Roers
Accelerated Wound Closure in Mice Deficient for Interleukin-10
Am. J. Pathol., January 1, 2007; 170(1): 188 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. S. Bharhani, R. Borojevic, S. Basak, E. Ho, P. Zhou, and K. Croitoru
IL-10 protects mouse intestinal epithelial cells from Fas-induced apoptosis via modulating Fas expression and altering caspase-8 and FLIP expression.
Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G820 - G829.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Robertson, R. J. Skinner, and A. S. Care
Essential Role for IL-10 in Resistance to Lipopolysaccharide-Induced Preterm Labor in Mice
J. Immunol., October 1, 2006; 177(7): 4888 - 4896.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. A. M. den Boer, P. J. Voshol, J. P. Schroder-van der Elst, E. Korsheninnikova, D. M. Ouwens, F. Kuipers, L. M. Havekes, and J. A. Romijn
Endogenous Interleukin-10 Protects against Hepatic Steatosis but Does Not Improve Insulin Sensitivity during High-Fat Feeding in Mice
Endocrinology, October 1, 2006; 147(10): 4553 - 4558.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. E. Foulds, M. J. Rotte, and R. A. Seder
IL-10 Is Required for Optimal CD8 T Cell Memory following Listeria monocytogenes Infection
J. Immunol., August 15, 2006; 177(4): 2565 - 2574.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kitagaki, T. R. Businga, D. Racila, D. E. Elliott, J. V. Weinstock, and J. N. Kline
Intestinal Helminths Protect in a Murine Model of Asthma
J. Immunol., August 1, 2006; 177(3): 1628 - 1635.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Scarpelli, M. Cardellini, F. Andreozzi, E. Laratta, M. L. Hribal, M. A. Marini, V. Tassi, R. Lauro, F. Perticone, and G. Sesti
Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects.
Diabetes, May 1, 2006; 55(5): 1529 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
D. Church, S. Elsayed, O. Reid, B. Winston, and R. Lindsay
Burn Wound Infections
Clin. Microbiol. Rev., April 1, 2006; 19(2): 403 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Overhaus, B. A. Moore, J. E. Barbato, F. F. Behrendt, J. G. Doering, and A. J. Bauer
Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators
Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G695 - G703.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Folch-Puy, S. Granell, J. C. Dagorn, J. L. Iovanna, and D. Closa
Pancreatitis-Associated Protein I Suppresses NF-{kappa}B Activation through a JAK/STAT-Mediated Mechanism in Epithelial Cells
J. Immunol., March 15, 2006; 176(6): 3774 - 3779.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. R. Pilione and E. T. Harvill
The Bordetella bronchiseptica Type III Secretion System Inhibits Gamma Interferon Production That Is Required for Efficient Antibody-Mediated Bacterial Clearance
Infect. Immun., February 1, 2006; 74(2): 1043 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. D. Huber, C. R. Campos, K. S. Mark, and T. P. Davis
Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after {lambda}-carrageenan-induced inflammatory pain
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H732 - H740.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Mizoguchi and A. K. Bhan
A Case for Regulatory B Cells
J. Immunol., January 15, 2006; 176(2): 705 - 710.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
W. Mu, X. Ouyang, A. Agarwal, L. Zhang, D. A. Long, P. E. Cruz, C. A. Roncal, O. Y. Glushakova, V. A. Chiodo, M. A. Atkinson, et al.
IL-10 Suppresses Chemokines, Inflammation, and Fibrosis in a Model of Chronic Renal Disease
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3651 - 3660.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M.-T. Lin, B. Storer, P. J. Martin, L.-H. Tseng, B. Grogan, P.-J. Chen, L. P. Zhao, and J. A. Hansen
Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor {beta} genotype of donor
Blood, December 1, 2005; 106(12): 3995 - 4001.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. K. Dahle, A. E. Myhre, A. O. Aasen, and J. E. Wang
Effects of Forskolin on Kupffer Cell Production of Interleukin-10 and Tumor Necrosis Factor Alpha Differ from Those of Endogenous Adenylyl Cyclase Activators: Possible Role for Adenylyl Cyclase 9
Infect. Immun., November 1, 2005; 73(11): 7290 - 7296.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. V. Lopez, S. K. Adris, A. I. Bravo, Y. Chernajovsky, and O. L. Podhajcer
IL-12 and IL-10 Expression Synergize to Induce the Immune-Mediated Eradication of Established Colon and Mammary Tumors and Lung Metastasis
J. Immunol., November 1, 2005; 175(9): 5885 - 5894.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. M. Andrade, M. Wessendarp, J.-A. C. Portillo, J.-Q. Yang, F. J. Gomez, J. E. Durbin, G. A. Bishop, and C. S. Subauste
TNF Receptor-Associated Factor 6-Dependent CD40 Signaling Primes Macrophages to Acquire Antimicrobial Activity in Response to TNF-{alpha}
J. Immunol., November 1, 2005; 175(9): 6014 - 6021.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. W. DePaolo, R. Lathan, B. J. Rollins, and W. J. Karpus
The Chemokine CCL2 Is Required for Control of Murine Gastric Salmonella enterica Infection
Infect. Immun., October 1, 2005; 73(10): 6514 - 6522.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Riemann, R. Endres, S. Liptay, K. Pfeffer, and R. M. Schmid
The I{kappa}B Protein Bcl-3 Negatively Regulates Transcription of the IL-10 Gene in Macrophages
J. Immunol., September 15, 2005; 175(6): 3560 - 3568.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Safadi, C. E. Alvarez, M. Ohta, J. Brimnes, T. Kraus, W. Mehal, J. Bromberg, L. Mayer, and S. L. Friedman
Enhanced Oral Tolerance in Transgenic Mice with Hepatocyte Secretion of IL-10
J. Immunol., September 15, 2005; 175(6): 3577 - 3583.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. J. Mitchell, A. M. Hansen, L. Hee, H. J. Ball, S. M. Potter, J. C. Walker, and N. H. Hunt
Early Cytokine Production Is Associated with Protection from Murine Cerebral Malaria
Infect. Immun., September 1, 2005; 73(9): 5645 - 5653.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. Straczkowski, I. Kowalska, A. Nikolajuk, A. Krukowska, and M. Gorska
Plasma Interleukin-10 Concentration Is Positively Related to Insulin Sensitivity in Young Healthy Individuals
Diabetes Care, August 1, 2005; 28(8): 2036 - 2037.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Nakagome, M. Dohi, K. Okunishi, Y. Komagata, K. Nagatani, R. Tanaka, J.-i. Miyazaki, and K. Yamamoto
In Vivo IL-10 Gene Delivery Suppresses Airway Eosinophilia and Hyperreactivity by Down-Regulating APC Functions and Migration without Impairing the Antigen-Specific Systemic Immune Response in a Mouse Model of Allergic Airway Inflammation
J. Immunol., June 1, 2005; 174(11): 6955 - 6966.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Furukawa, K. Oshima, T. Tung, G. Cui, H. Laks, and L. Sen
Liposome-Mediated Combinatorial Cytokine Gene Therapy Induces Localized Synergistic Immunosuppression and Promotes Long-Term Survival of Cardiac Allografts
J. Immunol., June 1, 2005; 174(11): 6983 - 6992.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Chen, M. H. Kapturczak, C. Wasserfall, O. Y. Glushakova, M. Campbell-Thompson, J. S. Deshane, R. Joseph, P. E. Cruz, W. W. Hauswirth, K. M. Madsen, et al.
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway
PNAS, May 17, 2005; 102(20): 7251 - 7256.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. S. Kang and P. M. Allen
Priming in the Presence of IL-10 Results in Direct Enhancement of CD8+ T Cell Primary Responses and Inhibition of Secondary Responses
J. Immunol., May 1, 2005; 174(9): 5382 - 5389.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Barbarin, Z. Xing, M. Delos, D. Lison, and F. Huaux
Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles
Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L841 - L848.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. L. Chelvarajan, S. M. Collins, J. M. Van Willigen, and S. Bondada
The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function
J. Leukoc. Biol., April 1, 2005; 77(4): 503 - 512.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
Y. Shibata, A. Nishiyama, H. Ohata, J. Gabbard, Q. N. Myrvik, and R. A. Henriksen
Differential effects of IL-10 on prostaglandin H synthase-2 expression and prostaglandin E2 biosynthesis between spleen and bone marrow macrophages
J. Leukoc. Biol., April 1, 2005; 77(4): 544 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
H. Beloeil, K. Asehnoune, P. Moine, D. Benhamou, and J.-X. Mazoit
Bupivacaine's Action on the Carrageenan-Induced Inflammatory Response in Mice: Cytokine Production by Leukocytes After Ex-Vivo Stimulation
Anesth. Analg., April 1, 2005; 100(4): 1081 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Ooboshi, S. Ibayashi, T. Shichita, Y. Kumai, J. Takada, T. Ago, S. Arakawa, H. Sugimori, M. Kamouchi, T. Kitazono, et al.
Postischemic Gene Transfer of Interleukin-10 Protects Against Both Focal and Global Brain Ischemia
Circulation, February 22, 2005; 111(7): 913 - 919.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Liu, S. J. O'Day, D. Yang, P. Boasberg, R. Milford, T. Kristedja, S. Groshen, and J. Weber
Impact of Gene Polymorphisms on Clinical Outcome for Stage IV Melanoma Patients Treated with Biochemotherapy: An Exploratory Study
Clin. Cancer Res., February 1, 2005; 11(3): 1237 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
V M Salvati, G Mazzarella, C Gianfrani, M K Levings, R Stefanile, B De Giulio, G Iaquinto, N Giardullo, S Auricchio, M G Roncarolo, et al.
Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa
Gut, January 1, 2005; 54(1): 46 - 53.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. Grutz
New insights into the molecular mechanism of interleukin-10-mediated immunosuppression
J. Leukoc. Biol., January 1, 2005; 77(1): 3 - 15.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Re and J. L. Strominger
IL-10 Released by Concomitant TLR2 Stimulation Blocks the Induction of a Subset of Th1 Cytokines That Are Specifically Induced by TLR4 or TLR3 in Human Dendritic Cells
J. Immunol., December 15, 2004; 173(12): 7548 - 7555.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. Hajishengallis, H. Nawar, R. I. Tapping, M. W. Russell, and T. D. Connell
The Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb and Their Respective B Pentamers Differentially Induce and Regulate Cytokine Production in Human Monocytic Cells
Infect. Immun., November 1, 2004; 72(11): 6351 - 6358.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
V. S. Carl, J. K. Gautam, L. D. Comeau, and M. F. Smith Jr
Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression
J. Leukoc. Biol., September 1, 2004; 76(3): 735 - 742.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Steinke, E. Barekzi, J. Hagman, and L. Borish
Functional Analysis of -571 IL-10 Promoter Polymorphism Reveals a Repressor Element Controlled by Sp1
J. Immunol., September 1, 2004; 173(5): 3215 - 3222.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Deng, K. Muthu, R. Gamelli, R. Shankar, and S. B. Jones
Adrenergic modulation of splenic macrophage cytokine release in polymicrobial sepsis
Am J Physiol Cell Physiol, September 1, 2004; 287(3): C730 - C736.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Rothwell, J. R. Young, R. Zoorob, C. A. Whittaker, P. Hesketh, A. Archer, A. L. Smith, and P. Kaiser
Cloning and Characterization of Chicken IL-10 and Its Role in the Immune Response to Eimeria maxima
J. Immunol., August 15, 2004; 173(4): 2675 - 2682.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. J. Kerschen, D. A. Cohen, A. M. Kaplan, and S. C. Straley
The Plague Virulence Protein YopM Targets the Innate Immune Response by Causing a Global Depletion of NK Cells
Infect. Immun., August 1, 2004; 72(8): 4589 - 4602.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kurte, M. Lopez, A. Aguirre, A. Escobar, J. C. Aguillon, J. Charo, C. G. Larsen, R. Kiessling, and F. Salazar-Onfray
A Synthetic Peptide Homologous to Functional Domain of Human IL-10 Down-Regulates Expression of MHC Class I and Transporter Associated with Antigen Processing 1/2 in Human Melanoma Cells
J. Immunol., August 1, 2004; 173(3): 1731 - 1737.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. Careau and E. Y. Bissonnette
Adoptive Transfer of Alveolar Macrophages Abrogates Bronchial Hyperresponsiveness
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 22 - 27.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.