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The Journal of Immunology, Vol 147, Issue 11 3780-3787, Copyright © 1991 by American Association of Immunologists
ARTICLES |
R McMurray, D Keisler, K Kanuckel, S Izui and SE Walker
Department of Medicine, University of Missouri-Columbia.
Prolactin, an anterior pituitary hormone, stimulates humoral and cell- mediated immunity. This study investigated effects of manipulating prolactin levels in the autoimmune B/W mouse model of SLE. A group of B/W females was treated with daily injections of the prolactin- suppressing drug, bromocriptine. These mice had delayed elevation of anti-DNA antibodies and serum IgG; longevity was increased compared to control mice. Functioning syngeneic pituitary glands, implanted under the renal capsule, produced prolonged hyperprolactinemia in a separate group of female B/W mice. Hyperprolactinemic animals were characterized by premature albuminuria, elevated circulating gp70IC and IgG, and accelerated mortality. Analyses of thymic and splenic lymphocytes revealed no differences in lymphocyte subpopulations in mice with altered prolactin levels. This is the first report to substantiate an immunomodulatory role for prolactin in B/W mice. Further evaluation of this model may identify specific means of intervening clinically with immunosuppressive hormone-modulating therapy in SLE.
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S E Walker, D Miller, D L Hill, and G R Komatireddy Prolactin, a pituitary hormone that modifies immune responses: Proceedings of the Mini-symposium on Prolactin and SLE, held at the 5th International Conference on Systemic Lupus Erythematosus, Cancun, Mexico Lupus, July 1, 1998; 7(6): 371 - 375. [PDF]
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P Jimena, M A Aguirre, A Lopez-Curbelo, M de Andres, C Garcia-Courtay, and M J Cuadrado Prolactin levels in patients with systemic lupus erythematosus: a case controlled study Lupus, July 1, 1998; 7(6): 383 - 386. [Abstract] [PDF]
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J M Miranda, R E Prieto, R Paniagua, G Garcia, D Amato, L Barile, and L J Jara Clinical significance of serum and urine prolactin levels in lupus glomerulonephritis Lupus, July 1, 1998; 7(6): 387 - 391. [Abstract] [PDF]
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S. E Walker, S. H Allen, R. W Hoffman, and R. W McMurray Review : Prolactin: a stimulator of disease activity in systemic lupus erythematosus Lupus, February 1, 1995; 4(1): 3 - 9. [PDF]
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S. E. Walker Prolactin: An Immune-Stimulating Peptide that Regulates Other Immune-Modulating Hormones Lupus, April 1, 1993; 2(2): 67 - 69. [PDF]
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C. Lavalle, A. Graef, V. Baca, M. Ramirez-Lacayo, F. Blanco-Favela, and O. Ortiz Review: Prolactin and Gonadal Hormones: A Key Relationship That May Have Clinical, Monitoring and Therapeutic Implications in Systemic Lupus Erythematosus Lupus, April 1, 1993; 2(2): 71 - 75. [PDF]
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