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The Journal of Immunology, Vol 147, Issue 10 3360-3369, Copyright © 1991 by American Association of Immunologists
ARTICLES |
G Panchamoorthy, J McLean, RL Modlin, CT Morita, S Ishikawa, MB Brenner and H Band
Laboratory of Immunochemistry, Dana-Farber Cancer Institute, Boston, MA 02115.
Little is known about the nature of Ag recognition by the TCR-gamma delta. The recent observation that gamma delta T cells preferentially recognize mycobacterial Ag provides a model to examine the molecular basis of gamma delta-TCR recognition. Here, examination of the Mycobacteria-stimulated peripheral blood T cells with TCR-specific mAb revealed a predominance of T cells bearing V gamma 2/V delta 2 gene products. PCR cloning and sequence analysis of the TCR chains demonstrated extensive junctional diversity indicating that the response was polyclonal. The marked in vitro gamma delta T cell response to Mycobacteria was also detected in newborns before encounters with foreign Ag and exclusively involved the same V-gene usage observed in adults. Together, these results suggest that a major mechanism of gamma delta T cell reactivity involves recognition mediated by germline-encoded segments of the TCR.
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