| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 147, Issue 10 3261-3267, Copyright © 1991 by American Association of Immunologists
ARTICLES |
DR DeSilva, KB Urdahl and MK Jenkins
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.
Murine Th1 clones that receive signals through their TCR in the absence of APC-derived co-stimulatory signals do not produce IL-2 and instead become anergic, i.e., they are subsequently unable to produce IL-2 in response to Ag and normal APC. The critical cellular event required to prevent the induction of this anergic state appears to be T cell proliferation. Anergy was induced when T cell clones were stimulated under conditions where both TCR occupancy and costimulatory signals were provided but where proliferation in response to the IL-2 produced was prevented. Once induced, anergy could be reversed if the T cells were allowed to undergo multiple rounds of cell division. These results show that anergy is induced as a consequence of TCR occupancy in the absence of cell division; this can be achieved either by limiting IL-2 production because of deficient provision of co-stimulatory signals or by preventing response to IL-2.
This article has been cited by other articles:
|
|
 |
|
  E. S. Mortensen, K. A. Fenton, and O. P. Rekvig Lupus Nephritis: The Central Role of Nucleosomes Revealed Am. J. Pathol., February 1, 2008; 172(2): 275 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Olazabal, N. B. Martin-Cofreces, M. Mittelbrunn, G. Martinez del Hoyo, B. Alarcon, and F. Sanchez-Madrid Activation Outcomes Induced in Naive CD8 T-Cells by Macrophages Primed via "Phagocytic" and Nonphagocytic Pathways Mol. Biol. Cell, February 1, 2008; 19(2): 701 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jane-wit, C. Z. Altuntas, J. Monti, J. M. Johnson, T. G. Forsthuber, and V. K. Tuohy Sex-Defined T-Cell Responses to Cardiac Self Determine Differential Outcomes of Murine Dilated Cardiomyopathy Am. J. Pathol., January 1, 2008; 172(1): 11 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Thomas, N. Chunder, C. Chen, S. E. Umetsu, S. Winandy, and A. D. Wells Ikaros Enforces the Costimulatory Requirement for IL2 Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes J. Immunol., December 1, 2007; 179(11): 7305 - 7315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Haniffa, X.-N. Wang, U. Holtick, M. Rae, J. D. Isaacs, A. M. Dickinson, C. M. U. Hilkens, and M. P. Collin Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells J. Immunol., August 1, 2007; 179(3): 1595 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Colombetti, V. Basso, D. L. Mueller, and A. Mondino Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin. J. Immunol., March 1, 2006; 176(5): 2730 - 2738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Rowell, M. C. Walsh, and A. D. Wells Opposing Roles for the Cyclin-Dependent Kinase Inhibitor p27kip1 in the Control of CD4+ T Cell Proliferation and Effector Function J. Immunol., March 15, 2005; 174(6): 3359 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Harris, K. D. Bishop, N. E. Phillips, J. P. Mordes, D. L. Greiner, A. A. Rossini, and M. P. Czech Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells J. Immunol., December 15, 2004; 173(12): 7331 - 7338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Allen, Y. Zheng, L. Gardner, M. Safford, M. R. Horton, and J. D. Powell The Novel Cyclophilin Binding Compound, Sanglifehrin A, Disassociates G1 Cell Cycle Arrest from Tolerance Induction J. Immunol., April 15, 2004; 172(8): 4797 - 4803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. NAMAZI Pyridoxal 5'-phosphate as a novel weapon against autoimmunity and transplant rejection FASEB J, December 1, 2003; 17(15): 2184 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Behbod, Z. S. Nagy, S. M. Stepkowski, J. Karras, C. R. Johnson, W. D. Jarvis, and R. A. Kirken Specific Inhibition of Stat5a/b Promotes Apoptosis of IL-2-Responsive Primary and Tumor-Derived Lymphoid Cells J. Immunol., October 15, 2003; 171(8): 3919 - 3927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Dillon, V. Karpitski, S. A. Wetzel, D. C. Parker, A. S. Shaw, and P. J. S. Stork Ectopic B-Raf Expression Enhances Extracellular Signal-regulated Kinase (ERK) Signaling in T Cells and Prevents Antigen-presenting Cell-induced Anergy J. Biol. Chem., September 19, 2003; 278(38): 35940 - 35949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Myers, C. Takahashi, R. S. Mittler, R. J. Rossi, and A. T. Vella Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering PNAS, April 29, 2003; 100(9): 5348 - 5353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yin, N. Dujovny, L. Ma, A. Varghese, J. Shen, D. K. Bishop, and A. S. Chong IFN-{gamma} Production Is Specifically Regulated by IL-10 in Mice Made Tolerant with Anti-CD40 Ligand Antibody and Intact Active Bone J. Immunol., January 15, 2003; 170(2): 853 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Trani, D. J. Moore, B. P. Jarrett, J. W. Markmann, M. K. Lee, A. Singer, M.-M. Lian, B. Tran, A. J. Caton, and J. F. Markmann CD25+ Immunoregulatory CD4 T Cells Mediate Acquired Central Transplantation Tolerance J. Immunol., January 1, 2003; 170(1): 279 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Bonnevier and D. L. Mueller Cutting Edge: B7/CD28 Interactions Regulate Cell Cycle Progression Independent of the Strength of TCR Signaling J. Immunol., December 15, 2002; 169(12): 6659 - 6663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Colombetti, F. Benigni, V. Basso, and A. Mondino Clonal Anergy Is Maintained Independently of T Cell Proliferation J. Immunol., December 1, 2002; 169(11): 6178 - 6186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Snyder, X. Zhang, and L. J. Wysocki Negligible Class II MHC Presentation of B Cell Receptor-Derived Peptides by High Density Resting B Cells J. Immunol., April 15, 2002; 168(8): 3865 - 3873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Stepkowski, R. A. Erwin-Cohen, F. Behbod, M.-E. Wang, X. Qu, N. Tejpal, Z. S. Nagy, B. D. Kahan, and R. A. Kirken Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin Blood, January 15, 2002; 99(2): 680 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Vanasek, A. Khoruts, T. Zell, and D. L. Mueller Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness J. Immunol., November 15, 2001; 167(10): 5636 - 5644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Diepolder, N. H. Gruener, J. T. Gerlach, M.-C. Jung, E. A. Wierenga, and G. R. Pape Different Levels of T-Cell Receptor Triggering Induce Distinct Functions in Hepatitis B and Hepatitis C Virus-Specific Human CD4+ T-Cell Clones J. Virol., September 1, 2001; 75(17): 7803 - 7810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-N. Avice, M. Rubio, M. Sergerie, G. Delespesse, and M. Sarfati Role of CD47 in the Induction of Human Naive T Cell Anergy J. Immunol., September 1, 2001; 167(5): 2459 - 2468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Gillespie, M. C. Dolan, J. Piesman, and R. G. Titus Identification of an IL-2 Binding Protein in the Saliva of the Lyme Disease Vector Tick, Ixodes scapularis J. Immunol., April 1, 2001; 166(7): 4319 - 4326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Behbod, R. A. Erwin-Cohen, M.-E. Wang, B. W. Trawick, X. Qu, R. Verani, B. D. Kahan, S. M. Stepkowski, and R. A. Kirken Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts J. Immunol., March 15, 2001; 166(6): 3724 - 3732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Wells, M. C. Walsh, D. Sankaran, and L. A. Turka T Cell Effector Function and Anergy Avoidance Are Quantitatively Linked to Cell Division J. Immunol., September 1, 2000; 165(5): 2432 - 2443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dooms, T. Van Belle, M. Desmedt, P. Rottiers, and J. Grooten Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy Blood, August 1, 2000; 96(3): 1006 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. P. M. Koenen and I. Joosten Blockade of CD86 and CD40 induces alloantigen-specific immunoregulatory T cells that remain anergic even after reversal of hyporesponsiveness Blood, May 15, 2000; 95(10): 3153 - 3161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Frauwirth, M.-L. Alegre, and C. B. Thompson Induction of T Cell Anergy in the Absence of CTLA-4/B7 Interaction J. Immunol., March 15, 2000; 164(6): 2987 - 2993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Adler, C.-T. Huang, G. S. Yochum, D. W. Marsh, and D. M. Pardoll In Vivo CD4+ T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions J. Immunol., January 15, 2000; 164(2): 649 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Korthauer, W. Nagel, E. M. Davis, M. M. Le Beau, R. S. Menon, E. O. Mitchell, C. A. Kozak, W. Kolanus, and J. A. Bluestone Anergic T Lymphocytes Selectively Express an Integrin Regulatory Protein of the Cytohesin Family J. Immunol., January 1, 2000; 164(1): 308 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Powell, C. G. Lerner, G. R. Ewoldt, and R. H. Schwartz The -180 Site of the IL-2 Promoter Is the Target of CREB/CREM Binding in T Cell Anergy J. Immunol., December 15, 1999; 163(12): 6631 - 6639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chen, V. Heath, A. O'Garra, J. Johnston, and M. McMahon Sustained Activation of the Raf-MEK-ERK Pathway Elicits Cytokine Unresponsiveness in T Cells J. Immunol., December 1, 1999; 163(11): 5796 - 5805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Munn, E. Shafizadeh, J. T. Attwood, I. Bondarev, A. Pashine, and A. L. Mellor Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism J. Exp. Med., May 3, 1999; 189(9): 1363 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Azar, H. Tamim, H. N. Beyhum, M. Z. Habbal, and W. Y. Almawi Type I (Insulin-Dependent) Diabetes Is a Th1- and Th2-Mediated Autoimmune Disease Clin. Vaccine Immunol., May 1, 1999; 6(3): 306 - 310. [Full Text] [PDF]
|
|
|
|
|
|
V. K. Tuohy, M. Yu, L. Yin, J. A. Kawczak, and R. Philip Kinkel Spontaneous Regression of Primary Autoreactivity during Chronic Progression of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis J. Exp. Med., April 5, 1999; 189(7): 1033 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kaufman, F. Andris, and O. Leo A logical analysis of T cell activation and anergy PNAS, March 30, 1999; 96(7): 3894 - 3899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Powell, C. G. Lerner, and R. H. Schwartz Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation J. Immunol., March 1, 1999; 162(5): 2775 - 2784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Taams, W. van Eden, and M. H. M. Wauben Dose-Dependent Induction of Distinct Anergic Phenotypes: Multiple Levels of T Cell Anergy J. Immunol., February 15, 1999; 162(4): 1974 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Faith, C. A. Akdis, M. Akdis, A. Joss, D. Wymann, and K. Blaser An Altered Peptide Ligand Specifically Inhibits Th2 Cytokine Synthesis by Abrogating TCR Signaling J. Immunol., February 1, 1999; 162(3): 1836 - 1842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-N. Malvey, M. K. Jenkins, and D. L. Mueller Peripheral Immune Tolerance Blocks Clonal Expansion but Fails to Prevent the Differentiation of Th1 Cells J. Immunol., September 1, 1998; 161(5): 2168 - 2177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. DeSilva, E. A. Jones, M. F. Favata, B. D. Jaffee, R. L. Magolda, J. M. Trzaskos, and P. A. Scherle Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy J. Immunol., May 1, 1998; 160(9): 4175 - 4181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. D. Korin and J. A. Zack Progression to the G1b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells J. Virol., April 1, 1998; 72(4): 3161 - 3168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Zuckerman, L. Pullen, and J. Miller Functional Consequences of Costimulation by ICAM-1 on IL-2 Gene Expression and T Cell Activation J. Immunol., April 1, 1998; 160(7): 3259 - 3268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Holländer, S. Zuklys, C. Morel, E. Mizoguchi, K. Mobisson, S. Simpson, C. Terhorst, W. Wishart, D. E. Golan, A. K. Bhan, et al. Monoallelic Expression of the Interleukin-2 Locus Science, March 27, 1998; 279(5359): 2118 - 2121. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Hayashi, D. Y. Loh, O. Kanagawa, and F. Wang Differences Between Responses of Naive and Activated T Cells to Anergy Induction J. Immunol., January 1, 1998; 160(1): 33 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Thomis and L. J. Berg Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function J. Exp. Med., January 20, 1997; 185(2): 197 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mondino and M. K. Jenkins Accumulation of Sequence-specific RNA-binding Proteins in the Cytosol of Activated T Cells Undergoing RNA Degradation and Apoptosis J. Biol. Chem., November 3, 1995; 270(44): 26593 - 26601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Lombardi, S Sidhu, R Batchelor, and R Lechler Anergic T cells as suppressor cells in vitro Science, June 10, 1994; 264(5165): 1587 - 1589. [Abstract] [PDF]
|
|
|
|
|
|
S.-M. Kang, B. Beverly, A.-C. Tran, K. Brorson, R. H. Schwartz, and M. J. Lenardot Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy Science, August 21, 1992; 257(5073): 1134 - 1138. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
