The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marodi, L.
Right arrow Articles by Johnston, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marodi, L.
Right arrow Articles by Johnston, R. B., Jr

The Journal of Immunology, Vol 146, Issue 8 2790-2794, Copyright © 1991 by American Association of Immunologists

ARTICLES

Mechanisms of host defense against Candida species. II. Biochemical basis for the killing of Candida by mononuclear phagocytes

L Marodi, JR Forehand and RB Johnston Jr
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104.

We studied the biochemical basis of candidacidal activity by comparing the killing of Candida albicans, a serious pathogen, and Candida parapsilosis, a low-grade pathogen, by human monocytes (Mo) and monocyte-derived macrophages. Mo killed C. parapsilosis significantly better than C. albicans. The two species triggered the respiratory burst and release of myeloperoxidase (MPO) and beta-glucuronidase in Mo to an equivalent extent. In contrast to Mo, macrophages killed both species to an equivalent extent. Mo exhibited a greater candida- stimulated respiratory burst than did monocyte-derived macrophages, and the respiratory burst was required for the killing of both species. C. parapsilosis was killed much more easily than C. albicans by exposure to low concentrations of hypochlorite or monochloramine, MPO-dependent oxidants released by Mo but not macrophages, which lack MPO. With six different Candida strains there was a significant correlation between killing by Mo and susceptibility to hypochlorite (r = 0.926) or monochloramine (r = 0.981) (p less than 0.01 for each). Species differences in resistance to killing by Mo may be related to differences in sensitivity to MPO-derived oxidants, and the ability of C. albicans to resist the effects of these oxidants may be a virulence factor associated with this species.


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
E. Canton, J. Peman, A. Valentin, A. Espinel-Ingroff, and M. Gobernado
In Vitro Activities of Echinocandins against Candida krusei Determined by Three Methods: MIC and Minimal Fungicidal Concentration Measurements and Time-Kill Studies
Antimicrob. Agents Chemother., July 1, 2009; 53(7): 3108 - 3111.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
A. L. Baltch, L. H. Bopp, R. P. Smith, W. J. Ritz, and P. B. Michelsen
Anticandidal effects of voriconazole and caspofungin, singly and in combination, against Candida glabrata, extracellularly and intracellularly in granulocyte-macrophage colony stimulating factor (GM-CSF)-activated human monocytes
J. Antimicrob. Chemother., December 1, 2008; 62(6): 1285 - 1290.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
L. H. Bopp, A. L. Baltch, W. J. Ritz, P. B. Michelsen, and R. P. Smith
Antifungal effect of voriconazole on intracellular Candida glabrata, Candida krusei and Candida parapsilosis in human monocyte-derived macrophages.
J. Med. Microbiol., July 1, 2006; 55(Pt 7): 865 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. L. Newman, B. Bhugra, A. Holly, and R. E. Morris
Enhanced Killing of Candida albicans by Human Macrophages Adherent to Type 1 Collagen Matrices via Induction of Phagolysosomal Fusion
Infect. Immun., February 1, 2005; 73(2): 770 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
L. Pitzurra, R. Fringuelli, S. Perito, F. Schiaffella, R. Barluzzi, F. Bistoni, and A. Vecchiarelli
A New Azole Derivative of 1,4-Benzothiazine Increases the Antifungal Mechanisms of Natural Effector Cells
Antimicrob. Agents Chemother., September 1, 1999; 43(9): 2170 - 2175.
[Abstract] [Full Text]

Home page
 J. Cell Sci.Home page
R Kaposzta, L Marodi, M Hollinshead, S Gordon, and R. da Silva
Rapid recruitment of late endosomes and lysosomes in mouse macrophages ingesting Candida albicans
J. Cell Sci., January 10, 1999; 112(19): 3237 - 3248.
[Abstract] [PDF]

Home page
 Infect. Immun.Home page
L. Marodi, C. Tournay, R. Kaposzta, R. B. Johnston Jr., and N. Moguilevsky
Augmentation of Human Macrophage Candidacidal Capacity by Recombinant Human Myeloperoxidase and GranulocyteMacrophage Colony-Stimulating Factor
Infect. Immun., June 1, 1998; 66(6): 2750 - 2754.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Kaposzta, P. Tree, L. Marodi, and S. Gordon
Characteristics of Invasive Candidiasis in Gamma Interferon- and Interleukin-4-Deficient Mice: Role of Macrophages in Host Defense against Candida albicans
Infect. Immun., April 1, 1998; 66(4): 1708 - 1717.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.