| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 146, Issue 8 2654-2658, Copyright © 1991 by American Association of Immunologists
ARTICLES |
C van Kooten, I Rensink, D Pascual-Salcedo, R van Oers and L Aarden
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.
The production of cytokines is a key event of inflammation. In this report we demonstrate that normal human T cells are capable to produce IL-1 alpha, IL-6, and TNF-alpha, cytokines formerly considered to be monokines. This production was optimal after stimulation with a combination of anti-CD2, PMA, and anti-CD28. All three cytokines were produced in a bioactive form. Both naive (CD4+CD45RA+) and memory (CD4+CD45RO+) subsets of T cells were shown to produce similar amounts of IL-6 and TNF-alpha. In contrast the production of IL-1 alpha was found to be completely restricted to the CD4+CD45RO+ subset. The finding that T cells are such potent producers of these important mediators of the inflammatory response might be a key observation in the appreciation of the role of T cells in chronic inflammation.
This article has been cited by other articles:
|
|
 |
|
  J. G. I. van Rietschoten, K. F. Verzijlbergen, S. I. Gringhuis, T. C. T. M. v. d. P. Kraan, J.-P. Bayley, E. A. Wierenga, P. A. Jones, J. M. Kooter, and C. L. Verweij Differentially methylated alleles in a distinct region of the human interleukin-1{alpha} promoter are associated with allele-specific expression of IL-1{alpha} in CD4+ T cells Blood, October 1, 2006; 108(7): 2143 - 2149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Bayley, J. G. I. van Rietschoten, A. M. Bakker, L. van Baarsen, E. L. Kaijzel, E. A. Wierenga, T. C. T. M. van der Pouw Kraan, T. W. J. Huizinga, and C. L. Verweij Allele-Specific Expression of the IL-1{alpha} Gene in Human CD4+ T Cell Clones J. Immunol., September 1, 2003; 171(5): 2349 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Civil, I. Rensink, L. A. Aarden, and C. L. Verweij Functional Disparity of Distinct CD28 Response Elements toward Mitogenic Responses J. Biol. Chem., November 26, 1999; 274(48): 34369 - 34374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Voronov, Y. Weinstein, D. Benharroch, E. Cagnano, R. Ofir, M. Dobkin, R. M. White, M. Zoller, V. Barak, S. Segal, et al. Antitumor and Immunotherapeutic Effects of Activated Invasive T Lymphoma Cells That Display Short-Term Interleukin 1{{alpha}} Expression Cancer Res., March 1, 1999; 59(5): 1029 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Malm, R. Lenkei, and B. Sjodin Effects of eccentric exercise on the immune system in men J Appl Physiol, February 1, 1999; 86(2): 461 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ohshima, L.-P. Yang, T. Uchiyama, Y. Tanaka, P. Baum, M. Sergerie, P. Hermann, and G. Delespesse OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4-Producing Effectors Blood, November 1, 1998; 92(9): 3338 - 3345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Meijer, V. Huysen, R.T.J. Smeenk, and A.J.G. Swaak Profiles of Cytokines (TNF{alpha} and IL-6) and Acute Phase Proteins (CRP and {alpha}1AG) related to the Disease Course in Patients with Systemic Lupus Erythematosus Lupus, December 1, 1993; 2(6): 359 - 365. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
