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The Journal of Immunology, Vol 146, Issue 7 2249-2252, Copyright © 1991 by American Association of Immunologists

ARTICLES

Autoantibodies to nucleolin in systemic lupus erythematosus and other diseases

S Minota, WN Jarjour, N Suzuki, Y Nojima, RA Roubey, T Mimura, A Yamada, T Hosoya, F Takaku and JB Winfield
Third Department of Internal Medicine, University of Tokyo, Japan.

The 110-kDa intracellular phosphoprotein (110K) described previously by this laboratory as a common IgM autoantigen in SLE and certain other systemic autoimmune disorders and viral infections is identified as nucleolin in the present investigation. Using rabbit antiserum to rat nucleolin as a probe, IgM autoantibody-reactive 110K co-migrated with human lymphocyte nucleolin in one- and two-dimensional immunoblots. Rabbit anti-nucleolin also specifically depleted autoreactive 110K from detergent lysates of human cells. Because nucleolin shares amino acid sequence similarity and/or forms dynamic particles with other prominent autoantigens, the present observation raises the possibility that the nucleolin/anti-nucleolin system may be of special significance for the development of humoral autoreactivity to nuclear Ag.


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