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The Journal of Immunology, Vol 146, Issue 6 1880-1884, Copyright © 1991 by American Association of Immunologists

ARTICLES

A Waldenstrom's macroglobulin with anti-G3m(b1) antibody activity

T Ota, S Oda, S Chiba, H Suzuki and S Eto
First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

A human monoclonal macroglobulin (IgM, K) from a patient (KI) with Waldenstrom's macroglobulinemia was shown to have antibody activity against a human IgG (Gm) allotype. In hemagglutination tests, only one anti-D serum with G3m(b0b1) reacted with macroglobulin KI. Antiglobulin specificity of macroglobulin KI was determined to be an anti-G3m(b1) antibody by hemagglutination inhibition tests. Fab fragments from macroglobulin KI could react with human IgG3 protein possessing G3m(b1), but Fc fragments could not react. Gm phenotype in IgG isolated from serum KI was determined to be Gm(a,z,g,b0,s,t,u). This is the first report of a Waldenstrom's macroglobulin with antiglobulin specificity against a Gm allotype.




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