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The Journal of Immunology, Vol 146, Issue 6 1801-1805, Copyright © 1991 by American Association of Immunologists

ARTICLES

IL-4 can correct defective IgE production in SJA/9 mice

HF Savelkoul, BW Seymour, L Sullivan and RL Coffman
Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.

SJA/9 mice are unable to produce significant serum IgE responses to either primary or secondary challenge with protein Ag or helminth parasites. Previous work has shown that this defect resides the T cell rather than with the B cells. These experiments test several possible explanations for the lack of IgE production in these mice. SJA/9 mice do not appear to overproduce IFN-gamma or any other antagonist of IL-4 function. Helminth parasite infection induces normal levels of IL-5- dependent eosinophilia, suggesting that there is not a complete absence of a Th2 response in these mice. The defect, however can be explained by a substantial reduction in IL-4 production in vivo and can be corrected by infusion with IL-4. The reason for this lack of IL-4 production is not yet clear and, paradoxically, SJA/9 T cells can be stimulated in vitro to produce IL-4 levels comparable to T cells from other strains.


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