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The Journal of Immunology, Vol 146, Issue 5 1455-1462, Copyright © 1991 by American Association of Immunologists

ARTICLES

Malignant and nonmalignant T cell lines from human T cell lymphotropic virus type I-negative patients with Sezary syndrome

JT Abrams, SR Lessin, SK Ghosh, PC Nowell, W Ju, EC Vonderheid, AH Rook and E DeFreitas
Wistar Institute, Philadelphia, PA 19104-4268.

The establishment of an in vitro model for cutaneous T cell lymphomas and Sezary syndrome has been difficult since T cells from individuals with these diseases do not proliferate in response to T cell mitogens. We found that conditioned media, collected from mitogen-activated PBMC from Sezary patients, contain an IL-2 receptor inducing factor. Despite their ostensible proliferative disorder, using a combination Sezary cell-conditioned media and rIL-2, we established IL-2 responsive, human T cell lymphotropic virus type I negative T cell lines from 23 patients, nine of which contain cells with the structural and/or genetic characteristics of neoplastic Sezary T cells.


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