| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 146, Issue 4 1163-1168, Copyright © 1991 by American Association of Immunologists
ARTICLES |
WJ Karpus and RH Swanborg
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201.
Nylon wool adherent, CD4+ T cells from the spleens of rats that have recovered from experimental autoimmune encephalomyelitis (EAE) inhibit the in vitro production of IFN-gamma, but not IL-2, by effector cells of EAE when cocultured in the presence of myelin basic protein Ag. When anti-transforming growth factor-beta (TGF-beta) antibodies are added to the co-cultures, IFN-gamma production is restored to normal levels. Irrelevant control antibodies have no effect. The same pattern of response was obtained with cells incubated in serum-free medium. In other experiments, purified TGF-beta was added to cultures of effector cells in the presence of antigen. TGF-beta inhibited the production of IFN-gamma by these cells in a dose-dependent manner, but had no apparent inhibitory effect on IL-2 production. Finally, supernatants from cultures containing effector cells and CD4+ suppressor cells plus Ag contained measurable amounts of TGF-beta, whereas supernatants from cultures of effector cells plus Ag contained no measurable amounts of TGF-beta. These results suggest that CD4+ Ts cells of EAE regulate effector cells of EAE through a mechanism that involves the secretion of TGF-beta and that the inhibitory function of this cytokine can be reversed with neutralizing antibodies directed against TGF-beta.
This article has been cited by other articles:
|
|
 |
|
  L. Das and A. D. Levine TGF-{beta} Inhibits IL-2 Production and Promotes Cell Cycle Arrest in TCR-Activated Effector/Memory T Cells in the Presence of Sustained TCR Signal Transduction J. Immunol., February 1, 2008; 180(3): 1490 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Hussain, D. Yang, D. Suki, K. Aldape, E. Grimm, and A. B. Heimberger The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses Neuro-oncol, July 1, 2006; 8(3): 261 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, J. Reddy, H. Ochi, D. Frenkel, V. K. Kuchroo, and H. L. Weiner Recovery from experimental allergic encephalomyelitis is TGF-{beta} dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells Int. Immunol., April 1, 2006; 18(4): 495 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Trivedi, P. C. Roberts, N. A. Wolf, and R. H. Swanborg NK Cells Inhibit T Cell Proliferation via p21-Mediated Cell Cycle Arrest J. Immunol., April 15, 2005; 174(8): 4590 - 4597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Conant and R. H. Swanborg Autoreactive T Cells Persist in Rats Protected against Experimental Autoimmune Encephalomyelitis and Can Be Activated through Stimulation of Innate Immunity J. Immunol., May 1, 2004; 172(9): 5322 - 5328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jiang, S. Curran, E. Ruiz-Vazquez, B. Liang, R. Winchester, and L. Chess Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V{beta} repertoire during experimental autoimmune encephalomyelitis PNAS, July 8, 2003; 100(14): 8378 - 8383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Braley-Mullen, K. Chen, Y. Wei, and S. Yu Role of TGF{beta} in Development of Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice J. Immunol., December 15, 2001; 167(12): 7111 - 7118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. C. de Lafaille, S. Muriglan, M.-J. Sunshine, Y. Lei, N. Kutchukhidze, G. C. Furtado, A. K. Wensky, D. Olivares-Villagomez, and J. J. Lafaille Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes"" J. Exp. Med., November 5, 2001; 194(9): 1349 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Lindsey and R. Jin Immune regulatory effects of central nervous system antigens in culture Int. Immunol., November 1, 2000; 12(11): 1605 - 1612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Bickerstaff, D. Xia, R. P. Pelletier, and C. G. Orosz Mechanisms of Graft Acceptance: Evidence That Plasminogen Activator Controls Donor-Reactive Delayed-Type Hypersensitivity Responses in Cardiac Allograft Acceptor Mice J. Immunol., May 15, 2000; 164(10): 5132 - 5139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Young, L. D. Lowe, S. S. Booth, M. J. Whitters, L. Nicholson, V. K. Kuchroo, and M. Collins IL-4, IL-10, IL-13, and TGF-{beta} from an Altered Peptide Ligand-Specific Th2 Cell Clone Down-Regulate Adoptive Transfer of Experimental Autoimmune Encephalomyelitis J. Immunol., April 1, 2000; 164(7): 3563 - 3572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Maron, W. W. Hancock, A. Slavin, M. Hattori, V. Kuchroo, and H. L. Weiner Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines Int. Immunol., September 1, 1999; 11(9): 1573 - 1580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Smeltz, N. A. Wolf, and R. H. Swanborg Inhibition of Autoimmune T Cell Responses in the DA Rat by Bone Marrow-Derived NK Cells In Vitro: Implications for Autoimmunity J. Immunol., August 1, 1999; 163(3): 1390 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Olivares-Villagomez, Y. Wang, and J. J. Lafaille Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein-specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis J. Exp. Med., November 16, 1998; 188(10): 1883 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Seder, T. Marth, M. C. Sieve, W. Strober, J. J. Letterio, A. B. Roberts, and B. Kelsall Factors Involved in the Differentiation of TGF-{beta}-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-{gamma} Have Opposing Effects, While TGF-{beta} Positively Regulates Its Own Production J. Immunol., June 15, 1998; 160(12): 5719 - 5728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-B. Hua and C. C. Wang Interferon-gamma Activation of a Mitogen-activated Protein Kinase, KFR1, in the Bloodstream Form of Trypanosoma brucei J. Biol. Chem., April 18, 1997; 272(16): 10797 - 10803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Chen, V. Kuchroo, J Inobe, D. Hafler, and H. Weiner Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis Science, August 26, 1994; 265(5176): 1237 - 1240. [Abstract] [PDF]
|
|
|
|
|
|
G Lombardi, S Sidhu, R Batchelor, and R Lechler Anergic T cells as suppressor cells in vitro Science, June 10, 1994; 264(5165): 1587 - 1589. [Abstract] [PDF]
|
|
|
|
|
|
D.-R. Koh, W.-P. Fung-Leung, A. Ho, D. Gray, H. Acha-Orbea, and T.-W. Mak Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8-/- Mice Science, May 22, 1992; 256(5060): 1210 - 1213. [Abstract] [PDF]
|
|
|
|
|
|
P Salgame, J. Abrams, C Clayberger, H Goldstein, J Convit, R. Modlin, and B. Bloom Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones Science, October 11, 1991; 254(5029): 279 - 282. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
