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The Journal of Immunology, Vol 146, Issue 4 1149-1154, Copyright © 1991 by American Association of Immunologists

ARTICLES

Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta 1

JR Gamble and MA Vadas
Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

Recombinant human transforming growth factor-beta (TGF-beta) was found to inhibit the adhesive phenotype of human umbilical vein endothelial cells for human PBL, purified T lymphocytes, and PHA-activated lymphoblasts. TGF-beta inhibited lymphocyte attachment to resting human umbilical vein endothelial cells and also to endothelial monolayers stimulated with the pro-inflammatory cytokines TNF-alpha and IL-1 beta. Our investigations also show that the ability of endothelial cells to respond to TGF-beta by altering their adhesiveness is lost with prolonged culture of the cells. However, this loss is selective as TGF- beta inhibits cell proliferation in both early and late passage endothelial cells. These results suggest that in vivo TGF-beta may inhibit the adhesive phenotype of endothelial cells and also may limit the immunologic response occurring at the endothelial cell barrier.


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