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The Journal of Immunology, Vol 146, Issue 4 1093-1098, Copyright © 1991 by American Association of Immunologists

ARTICLES

The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire

HR Bhayani and SM Hedrick
Department of Biology, University of California, San Diego, La Jolla 92093.

Allelic variants of MHC molecules expressed on cells of the thymus affect the selection and the specificity of the T cell repertoire. The selection is based on either the direct recognition by the TCR of the MHC molecules, or the recognition of a complex determinant formed by self-peptides bound to MHC molecules. In an analysis of the T cell repertoire in bone marrow chimeras that express allelic forms of MHC class II molecules in the thymus epithelium, we find that amino acid substitutions that are predicted to affect peptide binding influence the selection of the T cell repertoire during thymic selection.


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