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The Journal of Immunology, Vol 146, Issue 3 807-811, Copyright © 1991 by American Association of Immunologists

ARTICLES

Induction of tolerance to syngeneic IgE in neonatal mice

S Haba and A Nisonoff
Department of Biology, Brandeis University, Waltham, MA 02254.

We have previously shown that adult A/J mice are tolerant to syngeneic IgE at the level of T cells, but not B cells. T cells of mice are responsive until the age of 2 to 3 wk, which correlates with the time of appearance of serum IgE. Tolerance can be induced earlier by neonatal administration of IgE in saline. We report here that purified nonimmune adult B cells, but not T cells, can transfer the state of tolerance to neonatal mice. As few as 2 x 10(6) B cells are effective. If IgE-bearing or IgE-secreting cells prove to be responsible, the amount of cell-bound IgE that can induce tolerance must be very small. The results also indicate that suppressor T cells do not have a major role in maintenance of self-tolerance to IgE.




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