The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Abe, J.
Right arrow Articles by Leung, D. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abe, J.
Right arrow Articles by Leung, D. Y.

The Journal of Immunology, Vol 146, Issue 11 3747-3750, Copyright © 1991 by American Association of Immunologists

ARTICLES

Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B

J Abe, J Forrester, T Nakahara, JA Lafferty, BL Kotzin and DY Leung
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicines, Denver, CO 80206.

Streptococcal exotoxins have been implicated in the pathogenesis of a toxic shock-like syndrome and scarlet fever. Previous studies have demonstrated that these toxins are potent stimulators of human T cells and have structural homology to staphylococcal enterotoxins. In the current study, we investigated the mechanism by which streptococcal erythrogenic toxins type A (SPEA) and B (SPEB) activate T cells and compared it with anti-CD3 and the known "superantigen" staphylococcal enterotoxin B. SPEA was found to selectively activate T cells bearing V beta 8, V beta 12, and V beta 14, whereas SPEB selectively activated T cells bearing V beta 2 and V beta 8. Furthermore, fibroblasts transfected with MHC class II molecules were capable of presenting SPEA and SPEB to purified T cells. The T cell response to these toxins, however, was not MHC-restricted. Although the streptococcal exotoxins stimulated both CD4+ and CD8+ T cells, SPEA but not SPEB stimulated the CD4+ T cell subset proportionately more than the CD8+ T cell subset. Our results indicate that SPEA and SPEB, like the staphylococcal enterotoxins, are superantigens and suggest a mechanism by which they may mediate particular systemic syndromes associated with streptococcal infections.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
B. J. M. Vlaminckx, F. H. J. Schuren, R. C. Montijn, M. P. M. Caspers, A. C. Fluit, W. J. B. Wannet, L. M. Schouls, J. Verhoef, and W. T. M. Jansen
Determination of the Relationship between Group A Streptococcal Genome Content, M Type, and Toxic Shock Syndrome by a Mixed Genome Microarray
Infect. Immun., May 1, 2007; 75(5): 2603 - 2611.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Llewelyn, S. Sriskandan, N. Terrazzini, J. Cohen, and D. M. Altmann
The TCR V{beta} signature of bacterial superantigens spreads with stimulus strength
Int. Immunol., October 1, 2006; 18(10): 1433 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. Diao and M. Kohanawa
Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production
Infect. Immun., June 1, 2005; 73(6): 3745 - 3748.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Llewelyn, S. Sriskandan, M. Peakman, D. R. Ambrozak, D. C. Douek, W. W. Kwok, J. Cohen, and D. M. Altmann
HLA Class II Polymorphisms Determine Responses to Bacterial Superantigens
J. Immunol., February 1, 2004; 172(3): 1719 - 1726.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
B. J. M. Vlaminckx, E. M. Mascini, J. Schellekens, L. M. Schouls, A. Paauw, A. C. Fluit, R. Novak, J. Verhoef, and F. J. Schmitz
Site-Specific Manifestations of Invasive Group A Streptococcal Disease: Type Distribution and Corresponding Patterns of Virulence Determinants
J. Clin. Microbiol., November 1, 2003; 41(11): 4941 - 4949.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Unnikrishnan, D. M. Altmann, T. Proft, F. Wahid, J. Cohen, J. D. Fraser, and S. Sriskandan
The Bacterial Superantigen Streptococcal Mitogenic Exotoxin Z Is the Major Immunoactive Agent of Streptococcus pyogenes
J. Immunol., September 1, 2002; 169(5): 2561 - 2569.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
E. M. Mascini, M. Jansze, L. M. Schouls, A. C. Fluit, J. Verhoef, and H. van Dijk
Invasive and Noninvasive Group A Streptococcal Isolates with Different speA Alleles in The Netherlands: Genetic Relatedness and Production of Pyrogenic Exotoxins A and B
J. Clin. Microbiol., November 1, 1999; 37(11): 3469 - 3474.
[Abstract] [Full Text]

Home page
 Infect. Immun.Home page
T. F. Bruno, D. E. Buser, R. M. Syme, D. E. Woods, and C. H. Mody
Pseudomonas aeruginosa Exoenzyme S Is a Mitogen but Not a Superantigen for Human T Lymphocytes
Infect. Immun., July 1, 1998; 66(7): 3072 - 3079.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. TAKATA, J. ABE, H. TANAKA, Y. KITANO, S. DOI, T. KOHSAKA, and K. MIYASAKA
Intraalveolar Expression of Tumor Necrosis Factor-alpha Gene during Conventional and High-Frequency Ventilation
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 272 - 279.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.