| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 145, Issue 5 1364-1368, Copyright © 1990 by American Association of Immunologists
ARTICLES |
MA Nieto, A Gonzalez, A Lopez-Rivas, F Diaz-Espada and F Gambon
Instituto de Investigaciones Biomedicas, CSIC, Madrid, Spain.
In recent years, several studies have confirmed the clonal elimination of thymocytes with receptors that recognize Ag and MHC molecules present on the membrane of thymic stromal cells, a process that may be relevant to the establishment of self-tolerance. In our work, we show that anti-CD3 treatment of single positive CD4+ or CD8+ human medullary thymocytes (obtained by anti-CD1a plus C) induces their apoptotic death. Some events commonly associated with the early steps of normal activation (IL-2R expression, increase in cytoplasmic Ca2+) are also induced after anti-CD3 treatment. Nevertheless, IL-2 is not secreted by these activated cells. The addition of exogenous IL-2 inhibits the apoptosis induced by anti-CD3. We suggest that the lack of secretion of IL-2 by medullary thymocytes may be a physiologic mechanism implicated in the process of negative selection that leads to tolerance.
This article has been cited by other articles:
|
|
 |
|
  E. Ayroldi, G. Migliorati, S. Bruscoli, C. Marchetti, O. Zollo, L. Cannarile, F. D'Adamio, and C. Riccardi Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor {kappa}B Blood, August 1, 2001; 98(3): 743 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ayroldi, O. Zollo, L. Cannarile, F. D' Adamio, U. Grohmann, D. V. Delfino, and C. Riccardi Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2-Independent Inhibition of Fas/fasL Expression and Cell Death Blood, December 1, 1998; 92(11): 4212 - 4219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Hinton, C. A. Peterson, E. M. Dahly, and D. M. Ney IGF-I alters lymphocyte survival and regeneration in thymus and spleen after dexamethasone treatment Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R912 - R920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard Functional cleavage of the common cytokine receptor gamma chain (gamma c) by calpain PNAS, October 14, 1997; 94(21): 11534 - 11539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Jeon, M. G. Kang, Y. H. Kim, Y. H. Jin, C. Lee, H.-Y. Chung, H. Kwon, S. D. Park, and R. H. Seong A New Mouse Gene, SRG3, Related to the SWI3 of Saccharomyces cerevisiae, Is Required for Apoptosis Induced by Glucocorticoids in a Thymoma Cell Line J. Exp. Med., May 19, 1997; 185(10): 1827 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ayroldi, G. Migliorati, L. Cannarile, R. Moraca, D. V. Delfino, and C. Riccardi CD2 Rescues T Cells From T-Cell Receptor/CD3 Apoptosis: A Role for the Fas/Fas-L System Blood, May 15, 1997; 89(10): 3717 - 3726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. B. E. Oldenburg, R. B. Evans-Storms, and J. A. Cidlowski In Vivo Resistance to Glucocorticoid-Induced Apoptosis in Rat Thymocytes with Normal Steroid Receptor Function in Vitro Endocrinology, February 1, 1997; 138(2): 810 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fauci Multifactorial nature of human immunodeficiency virus disease: implications for therapy Science, November 12, 1993; 262(5136): 1011 - 1018. [Abstract] [PDF]
|
|
|
|
|
|
L. Turka, D. Schatz, M. Oettinger, J. Chun, C Gorka, K Lee, W. McCormack, and C. Thompson Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking Science, August 16, 1991; 253(5021): 778 - 781. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
