| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 145, Issue 11 3618-3627, Copyright © 1990 by American Association of Immunologists
ARTICLES |
S Murakami, K Miyake, CH June, PW Kincade and RJ Hodes
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Pgp-1 expression was examined in unstimulated B cell populations and in B cells activated with several polyclonal stimuli. Flow cytometry analysis demonstrated that Pgp-1 expression increased when B cells were activated with supernatant of cloned Th2 cells, with LPS, or with IL-5, stimuli that induced polyclonal proliferation and differentiation. IL-5- primed B cells were phenotypically unique and could be divided into two distinct subpopulations based on the brightness of Pgp-1 expression. Furthermore, sterile sorting experiments showed that proliferating and differentiating B cells were highly enriched in a Pgp-1-bright, Ia- dull, B220-dull subpopulation. The possibility that Pgp-1 expressed on activated B cells functions as an adhesion molecule was evaluated by assessing adhesion of activated B cells to defined substrates. It was found that IL-5-activated B cells bound strongly to hyaluronate-coated surface, and this binding was specifically inhibited by anti-Pgp-1 Ab. These findings suggest that Pgp-1 expression is a useful marker which, under defined conditions, identifies the proliferating and differentiating subset of activated B cells. Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells.
This article has been cited by other articles:
|
|
 |
|
  J. P. Mishra, S. Mishra, K. Gee, and A. Kumar Differential Involvement of Calmodulin-dependent Protein Kinase II-activated AP-1 and c-Jun N-terminal Kinase-activated EGR-1 Signaling Pathways in Tumor Necrosis Factor-{alpha} and Lipopolysaccharide-induced CD44 Expression in Human Monocytic Cells J. Biol. Chem., July 22, 2005; 280(29): 26825 - 26837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gee, M. Kozlowski, and A. Kumar Tumor Necrosis Factor-{alpha} Induces Functionally Active Hyaluronan-adhesive CD44 by Activating Sialidase through p38 Mitogen-activated Protein Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells J. Biol. Chem., September 26, 2003; 278(39): 37275 - 37287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Gee, W. Lim, W. Ma, D. Nandan, F. Diaz-Mitoma, M. Kozlowski, and A. Kumar Differential Regulation of CD44 Expression by Lipopolysaccharide (LPS) and TNF-{alpha} in Human Monocytic Cells: Distinct Involvement of c-Jun N-Terminal Kinase in LPS-Induced CD44 Expression J. Immunol., November 15, 2002; 169(10): 5660 - 5672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Delcommenne, R. Kannagi, and P. Johnson TNF-{alpha} increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans Glycobiology, October 1, 2002; 12(10): 613 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-B. Yang, M. Martin, S. M. Michalek, and J. Katz Mechanisms of Monophosphoryl Lipid A Augmentation of Host Responses to Recombinant HagB from Porphyromonas gingivalis Infect. Immun., July 1, 2002; 70(7): 3557 - 3565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fujimoto, H. Kawashima, T. Tanaka, M. Hirose, N. Toyama-Sorimachi, Y. Matsuzawa, and M. Miyasaka CD44 binds a chondroitin sulfate proteoglycan, aggrecan Int. Immunol., March 1, 2001; 13(3): 359 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Levesque and B. F. Haynes Activated T Lymphocytes Regulate Hyaluronan Binding to Monocyte CD44 Via Production of IL-2 and IFN-{{gamma}} J. Immunol., January 1, 2001; 166(1): 188 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. FOSTER, P. WIESEL, G. S. HUGGINS, R. PAÑARES, M. T. CHIN, A. PELLACANI, and M. A. PERRELLA Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1{beta} in vascular smooth muscle cells FASEB J, February 1, 2000; 14(2): 368 - 378. [Abstract] [Full Text]
|
|
|
|
|
|
S. Seiter, D.-S. Schmidt, and M. Zoller The CD44 variant isoforms CD44v6 and CD44v7 are expressed by distinct leukocyte subpopulations and exert non-overlapping functional activities Int. Immunol., January 1, 2000; 12(1): 37 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang and M. J. Shlomchik Autoantigen-Specific B Cell Activation in FAS-Deficient Rheumatoid Factor Immunoglobulin Transgenic Mice J. Exp. Med., September 6, 1999; 190(5): 639 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ingvarsson, K. Dahlenborg, R. Carlsson, and C. A. K. Borrebaeck Co-ligation of CD44 on naive human tonsillar B cells induces progression towards a germinal center phenotype Int. Immunol., May 1, 1999; 11(5): 739 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Katoh, T. Miyagi, H. Taniguchi, Y.-i. Matsubara, J.-i. Kadota, A. Tominaga, P. W. Kincade, S. Matsukura, and S. Kohno Cutting Edge: An Inducible Sialidase Regulates the Hyaluronic Acid Binding Ability of CD44-Bearing Human Monocytes J. Immunol., May 1, 1999; 162(9): 5058 - 5061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Wise, T. J. Baginski, and J. L. Mobley An Adoptive Transfer Model of Allergic Lung Inflammation in Mice Is Mediated by CD4+CD62LlowCD25+ T Cells J. Immunol., May 1, 1999; 162(9): 5592 - 5600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rachmilewitz and M. L. Tykocinski Differential Effects of Chondroitin Sulfates A and B on Monocyte and B-Cell Activation: Evidence for B-Cell Activation Via a CD44-Dependent Pathway Blood, July 1, 1998; 92(1): 223 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matsumoto, M. P. Nghiem, N. Nozaki, R. Schmits, and J. M. Penninger Cooperation Between CD44 and LFA-1/CD11a Adhesion Receptors in Lymphokine-Activated Killer Cell Cytotoxicity J. Immunol., June 15, 1998; 160(12): 5781 - 5789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Matsumoto, J. Appiah-Pippim, R. P. Schleimer, C. A. Bickel, L. A. Beck, and B. S. Bochner CD44 and CD69 Represent Different Types of Cell-surface Activation Markers for Human Eosinophils Am. J. Respir. Cell Mol. Biol., June 1, 1998; 18(6): 860 - 866. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Esford, A Maiti, S. Bader, F Tufaro, and P Johnson Analysis of CD44 interactions with hyaluronan in murine L cell fibroblasts deficient in glycosaminoglycan synthesis: a role for chondroitin sulfate J. Cell Sci., January 4, 1998; 111(7): 1021 - 1029. [Abstract] [PDF]
|
|
|
|
|
|
S. Legras, J.-P. Levesque, R. Charrad, K. Morimoto, C. Le Bousse, D. Clay, C. Jasmin, and F. Smadja-Joffe CD44-Mediated Adhesiveness of Human Hematopoietic Progenitors to Hyaluronan Is Modulated by Cytokines Blood, March 15, 1997; 89(6): 1905 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Murakami and H. Okada Lymphocyte-Fibroblast Interactions Critical Reviews in Oral Biology & Medicine, January 1, 1997; 8(1): 40 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Murakami, T. Saho, A. Asari, E. Hino, D. Kasai, Y. Shimabukuro, and H. Okada CD44-Hyaluronate Interaction Participates in the Adherence of T-lymphocytes to Gingival Fibroblasts Journal of Dental Research, August 1, 1996; 75(8): 1545 - 1552. [Abstract] [PDF]
|
|
|
|
|
|
N. Toyama-Sorimachi, H. Sorimachi, Y. Tobita, F. Kitamura, H. Yagita, K. Suzuki, and M. Miyasaka A Novel Ligand for CD44 Is Serglycin, a Hematopoietic Cell Lineage-specific Proteoglycan J. Biol. Chem., March 31, 1995; 270(13): 7437 - 7444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kawashima, M. Hirose, J. Hirose, D. Nagakubo, A. H. K. Plaas, and M. Miyasaka Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44 J. Biol. Chem., November 3, 2000; 275(45): 35448 - 35456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cichy and E. Pure Oncostatin M and Transforming Growth Factor-beta 1 Induce Post-translational Modification and Hyaluronan Binding to CD44 in Lung-derived Epithelial Tumor Cells J. Biol. Chem., June 9, 2000; 275(24): 18061 - 18069. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
