| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 145, Issue 11 3589-3593, Copyright © 1990 by American Association of Immunologists
ARTICLES |
G Koopman, Y van Kooyk, M de Graaff, CJ Meyer, CG Figdor and ST Pals
Department of Pathology, Free University, Amsterdam, The Netherlands.
The CD44 molecule, a molecule which has been previously known as Hermes, Pgp-1, extracellular matrix receptor III, and In(Lu)-related p80, is currently thought to be involved in several steps of normal immune cell function, including lymphocyte adhesion to high endothelial venules and to the extracellular matrix and T cell activation. We now demonstrate that triggering of CD44 on T lymphocytes by anti-CD44 mAb promotes cell adhesion. The induced homotypic adhesion is mediated by lymphocyte function-associated antigen-1 (LFA-1), because it was inhibited by anti-LFA-1 antibodies and not by anti-LFA-3 antibodies. This notion is supported by the temperature and Mg2+ dependence which is characteristic of LFA-1-mediated adhesion. Moreover, the sensitivity of CD44-induced adhesion to AMG and H7, which both prevent the activation of protein kinase C, and to cytochalasin B, which inhibits microfilament formation, suggests that the activation of the LFA-1 pathway via CD44 involves protein kinase C activation and requires an intact cytoskeleton.
This article has been cited by other articles:
|
|
 |
|
  E. Vachon, R. Martin, V. Kwok, V. Cherepanov, C.-W. Chow, C. M. Doerschuk, J. Plumb, S. Grinstein, and G. P. Downey CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages Blood, December 15, 2007; 110(13): 4492 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Thibault, M. R. Tardif, C. Barat, and M. J. Tremblay TLR2 Signaling Renders Quiescent Naive and Memory CD4+ T Cells More Susceptible to Productive Infection with X4 and R5 HIV-Type 1 J. Immunol., October 1, 2007; 179(7): 4357 - 4366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Singh, B.J. Campbell, L.-G. Yu, D.G. Fernig, J.D. Milton, R.A. Goodlad, A.J. FitzGerald, and J.M. Rhodes Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44 Glycobiology, July 1, 2001; 11(7): 587 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Foger, R Marhaba, and M Zoller Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells J. Cell Sci., January 3, 2001; 114(6): 1169 - 1178. [Abstract] [PDF]
|
|
|
|
|
|
L. Airas, J. Niemela, and S. Jalkanen CD73 Engagement Promotes Lymphocyte Binding to Endothelial Cells Via a Lymphocyte Function-Associated Antigen-1-Dependent Mechanism J. Immunol., November 15, 2000; 165(10): 5411 - 5417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Drillenburg and S. T. Pals Cell adhesion receptors in lymphoma dissemination Blood, March 15, 2000; 95(6): 1900 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Protin, T. Schweighoffer, W. Jochum, and F. Hilberg CD44-Deficient Mice Develop Normally with Changes in Subpopulations and Recirculation of Lymphocyte Subsets J. Immunol., November 1, 1999; 163(9): 4917 - 4923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. M. Soede, M. H. E. Driessens, L. Ruuls-Van Stalle, P. E. M. Van Hulten, A. Brink, and E. Roos LFA-1 to LFA-1 Signals Involve {zeta}-Associated Protein-70 (ZAP-70) Tyrosine Kinase: Relevance for Invasion and Migration of a T Cell Hybridoma J. Immunol., October 15, 1999; 163(8): 4253 - 4261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M SALMI and S JALKANEN Molecules controlling lymphocyte migration to the gut Gut, July 1, 1999; 45(1): 148 - 153. [Full Text] [PDF]
|
|
|
|
|
|
A. Kotovuori, T. Pessa-Morikawa, P. Kotovuori, P. Nortamo, and C. G. Gahmberg ICAM-2 and a Peptide from Its Binding Domain Are Efficient Activators of Leukocyte Adhesion and Integrin Affinity J. Immunol., June 1, 1999; 162(11): 6613 - 6620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Rey-Ladino, M. Huber, L. Liu, J. E. Damen, G. Krystal, and F. Takei The SH2-Containing Inositol-5'-Phosphatase Enhances LFA-1-Mediated Cell Adhesion and Defines Two Signaling Pathways for LFA-1 Activation J. Immunol., May 15, 1999; 162(10): 5792 - 5799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Haegel-Kronenberger, H. de la Salle, A. Bohbot, F. Oberling, J.-P. Cazenave, and D. Hanau Adhesive and/or Signaling Functions of CD44 Isoforms in Human Dendritic Cells J. Immunol., October 15, 1998; 161(8): 3902 - 3911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ristamaki, H. Joensuu, K. Lappalainen, L. Teerenhovi, and S. Jalkanen Elevated Serum CD44 Level Is Associated With Unfavorable Outcome in Non-Hodgkin's Lymphoma Blood, November 15, 1997; 90(10): 4039 - 4045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Toyama-Sorimachi, F. Kitamura, H. Habuchi, Y. Tobita, K. Kimata, and M. Miyasaka Widespread Expression of Chondroitin Sulfate-type Serglycins with CD44 Binding Ability in Hematopoietic Cells J. Biol. Chem., October 17, 1997; 272(42): 26714 - 26719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Griffioen, M. J.H. Coenen, C. A. Damen, S. M.M. Hellwig, D. H.J. van Weering, W. Vooys, G. H. Blijham, and G. Groenewegen CD44 Is Involved in Tumor Angiogenesis; an Activation Antigen on Human Endothelial Cells Blood, August 1, 1997; 90(3): 1150 - 1159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hanninen, I. Jaakkola, M. Salmi, O. Simell, and S. Jalkanen Ly-6C regulates endothelial adhesion and homing of CD8+ T cells by activating integrin-dependent adhesion pathways PNAS, June 24, 1997; 94(13): 6898 - 6903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Legras, J.-P. Levesque, R. Charrad, K. Morimoto, C. Le Bousse, D. Clay, C. Jasmin, and F. Smadja-Joffe CD44-Mediated Adhesiveness of Human Hematopoietic Progenitors to Hyaluronan Is Modulated by Cytokines Blood, March 15, 1997; 89(6): 1905 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. I. Taher, L. Smit, A. W. Griffioen, E. J. M. Schilder-Tol, J. Borst, and S. T. Pals Signaling through CD44 Is Mediated by Tyrosine Kinases J. Biol. Chem., February 2, 1996; 271(5): 2863 - 2867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Li, N. Wong, M. D. Jabali, and P. Johnson CD44-initiated Cell Spreading Induces Pyk2 Phosphorylation, Is Mediated by Src Family Kinases, and Is Negatively Regulated by CD45 J. Biol. Chem., July 27, 2001; 276(31): 28767 - 28773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fagerholm, N. Morrice, C. G. Gahmberg, and P. Cohen Phosphorylation of the Cytoplasmic Domain of the Integrin CD18 Chain by Protein Kinase C Isoforms in Leukocytes J. Biol. Chem., January 11, 2002; 277(3): 1728 - 1738. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
