| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 145, Issue 1 149-154, Copyright © 1990 by American Association of Immunologists
ARTICLES |
PF Barnes, SJ Fong, PJ Brennan, PE Twomey, A Mazumder and RL Modlin
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
TNF and IFN-gamma are thought to be involved in the immune response to mycobacterial infection because they exhibit antimycobacterial effects in vitro. To investigate the roles of these cytokines in vivo at the site of disease activity in human tuberculosis, we evaluated local cytokine production in patients with tuberculous pleuritis. Both TNF and IFN-gamma were selectively concentrated 5- to 30-fold in pleural fluid, compared to blood of the same patients. Messenger RNA for both cytokines was detected in pleural tissue by in situ hybridization, suggesting that selective cytokine concentration is due to local cytokine production. Two Mycobacterium tuberculosis cell wall components, the protein-peptidoglycan complex and lipoarabinomannan, caused dose-dependent release of TNF by pleural fluid mononuclear cells and may constitute the stimuli for TNF production in the pleural space. In contrast to results obtained for TNF release, the protein- peptidoglycan complex, but not lipoarabinomannan, stimulated IFN-gamma release by pleural fluid mononuclear cells. The clinical manifestations of tuberculous pleuritis, such as fever, exudative pleural effusion, and tissue necrosis, may be due to the effects of elevated local TNF concentrations, produced in response to mycobacterial cell wall components.
This article has been cited by other articles:
|
|
 |
|
  Z. D. Daniil, E. Zintzaras, T. Kiropoulos, A. I. Papaioannou, A. Koutsokera, A. Kastanis, and K. I. Gourgoulianis Discrimination of exudative pleural effusions based on multiple biological parameters Eur. Respir. J., November 1, 2007; 30(5): 957 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Z. Kincaid, A. J. Wolf, L. Desvignes, S. Mahapatra, D. C. Crick, P. J. Brennan, M. S. Pavelka Jr., and J. D. Ernst Codominance of TLR2-Dependent and TLR2-Independent Modulation of MHC Class II in Mycobacterium tuberculosis Infection In Vivo J. Immunol., September 1, 2007; 179(5): 3187 - 3195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Jiang, H.-Z. Shi, Q.-L. Liang, S.-M. Qin, and X.-J. Qin Diagnostic Value of Interferon-{gamma} in Tuberculous Pleurisy: A Metaanalysis Chest, April 1, 2007; 131(4): 1133 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Garg, P. F. Barnes, A. Porgador, S. Roy, S. Wu, J. S. Nanda, D. E. Griffith, W. M. Girard, N. Rawal, S. Shetty, et al. Vimentin Expressed on Mycobacterium tuberculosis-Infected Human Monocytes Is Involved in Binding to the NKp46 Receptor J. Immunol., November 1, 2006; 177(9): 6192 - 6198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jeevan, C. T. McFarland, T. Yoshimura, T. Skwor, H. Cho, T. Lasco, and D. N. McMurray Production and Characterization of Guinea Pig Recombinant Gamma Interferon and Its Effect on Macrophage Activation Infect. Immun., January 1, 2006; 74(1): 213 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Fortune, A. Solache, A. Jaeger, P. J. Hill, J. T. Belisle, B. R. Bloom, E. J. Rubin, and J. D. Ernst Mycobacterium tuberculosis Inhibits Macrophage Responses to IFN-{gamma} through Myeloid Differentiation Factor 88-Dependent and -Independent Mechanisms J. Immunol., May 15, 2004; 172(10): 6272 - 6280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qiao, S. Prabhakar, A. Canova, Y. Hoshino, M. Weiden, and R. Pine Posttranscriptional Inhibition of Gene Expression by Mycobacterium tuberculosis Offsets Transcriptional Synergism with IFN-{gamma} and Posttranscriptional Up-Regulation by IFN-{gamma} J. Immunol., March 1, 2004; 172(5): 2935 - 2943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Z. Kincaid and J. D. Ernst Mycobacterium tuberculosis Exerts Gene-Selective Inhibition of Transcriptional Responses to IFN-{gamma} Without Inhibiting STAT1 Function J. Immunol., August 15, 2003; 171(4): 2042 - 2049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Allen and D. N. McMurray Coordinate Cytokine Gene Expression In Vivo following Induction of Tuberculous Pleurisy in Guinea Pigs Infect. Immun., August 1, 2003; 71(8): 4271 - 4277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V.B. Antony Immunological mechanisms in pleural disease Eur. Respir. J., March 1, 2003; 21(3): 539 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jeevan, T. Yoshimura, K. E. Lee, and D. N. McMurray Differential Expression of Gamma Interferon mRNA Induced by Attenuated and Virulent Mycobacterium tuberculosis in Guinea Pig Cells after Mycobacterium bovis BCG Vaccination Infect. Immun., January 1, 2003; 71(1): 354 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gilbertson and C. Cheers Generalized Immunological Decline during Long-Term Experimental Infection with Mycobacterium avium Infect. Immun., December 1, 2002; 70(12): 7145 - 7148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Aleman, A. Garcia, M. A. Saab, S. S. de la Barrera, M. Finiasz, E. Abbate, and M. C. Sasiain Mycobacterium tuberculosis-Induced Activation Accelerates Apoptosis in Peripheral Blood Neutrophils from Patients with Active Tuberculosis Am. J. Respir. Cell Mol. Biol., November 1, 2002; 27(5): 583 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Vordermeier, M. A. Chambers, P. J. Cockle, A. O. Whelan, J. Simmons, and R. G. Hewinson Correlation of ESAT-6-Specific Gamma Interferon Production with Pathology in Cattle following Mycobacterium bovis BCG Vaccination against Experimental Bovine Tuberculosis Infect. Immun., June 1, 2002; 70(6): 3026 - 3032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Roach, A. G. D. Bean, C. Demangel, M. P. France, H. Briscoe, and W. J. Britton TNF Regulates Chemokine Induction Essential for Cell Recruitment, Granuloma Formation, and Clearance of Mycobacterial Infection J. Immunol., May 1, 2002; 168(9): 4620 - 4627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jeevan, T. Yoshimura, G. Foster, and D. N. McMurray Effect of Mycobacterium bovis BCG Vaccination on Interleukin-1{beta} and RANTES mRNA Expression in Guinea Pig Cells Exposed to Attenuated and Virulent Mycobacteria Infect. Immun., March 1, 2002; 70(3): 1245 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Xirouchaki, N. Tzanakis, D. Bouros, D. Kyriakou, N. Karkavitsas, M. Alexandrakis, and N. M. Siafakas Diagnostic Value of Interleukin-1{alpha}, Interleukin-6, and Tumor Necrosis Factor in Pleural Effusions Chest, March 1, 2002; 121(3): 815 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Engele, K. Castiglione, N. Schwerdtner, M. Wagner, P. Bolcskei, M. Rollinghoff, and S. Stenger Induction of TNF in Human Alveolar Macrophages As a Potential Evasion Mechanism of Virulent Mycobacterium tuberculosis J. Immunol., February 1, 2002; 168(3): 1328 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Warwick-Davies, A. J. Watson, G. E. Griffin, S. Krishna, and R. J. Shattock Enhancement of Mycobacterium tuberculosis-Induced Tumor Necrosis Factor Alpha Production from Primary Human Monocytes by an Activated T-Cell Membrane-Mediated Mechanism Infect. Immun., November 1, 2001; 69(11): 6580 - 6587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shah, C. Whalen, D. P. Kotler, H. Mayanja, A. Namale, G. Melikian, R. Mugerwa, and R. D. Semba Severity of Human Immunodeficiency Virus Infection Is Associated with Decreased Phase Angle, Fat Mass and Body Cell Mass in Adults with Pulmonary Tuberculosis Infection in Uganda J. Nutr., November 1, 2001; 131(11): 2843 - 2847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Odeh, E. Sabo, I. Srugo, and A. Oliven Tumour necrosis factor alpha in the diagnostic assessment of pleural effusion QJM, December 1, 2000; 93(12): 819 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zaitseva, S. Lee, C. Lapham, R. Taffs, L. King, T. Romantseva, J. Manischewitz, and H. Golding Interferon gamma and interleukin 6 modulate the susceptibility of macrophages to human immunodeficiency virus type 1 infection Blood, November 1, 2000; 96(9): 3109 - 3117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kremer, J. Estaquier, I. Wolowczuk, F. Biet, J.-C. Ameisen, and C. Locht Ineffective Cellular Immune Response Associated with T-Cell Apoptosis in Susceptible Mycobacterium bovis BCG-Infected Mice Infect. Immun., July 1, 2000; 68(7): 4264 - 4273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nasreen, K. A. Mohammed, G. Galffy, M. J. Ward, and V. B. Antony MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells Am J Physiol Lung Cell Mol Physiol, March 1, 2000; 278(3): L591 - L598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-M. Ting, A. C. Kim, A. Cattamanchi, and J. D. Ernst Mycobacterium tuberculosis Inhibits IFN-{gamma} Transcriptional Responses Without Inhibiting Activation of STAT1 J. Immunol., October 1, 1999; 163(7): 3898 - 3906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Wilkinson, P. Patel, M. Llewelyn, C. S. Hirsch, G. Pasvol, G. Snounou, R. N. Davidson, and Z. Toossi Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1beta on Tuberculosis J. Exp. Med., June 21, 1999; 189(12): 1863 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. MOHAMMED, N. NASREEN, M. J. WARD, and V. B. ANTONY Helper T Cell Type 1 and 2 Cytokines Regulate C-C Chemokine Expression in Mouse Pleural Mesothelial Cells Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1653 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. P. JUFFERMANS, A. VERBON, S. J. H. van DEVENTER, H. van DEUTEKOM, P. SPEELMAN, and T. van der POLL Tumor Necrosis Factor and Interleukin-1 Inhibitors as Markers of Disease Activity of Tuberculosis Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1328 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. MARIE, M.-R. LOSSER, C. FITTING, N. KERMARREC, D. PAYEN, and J.-M. CAVAILLON Cytokines and Soluble Cytokine Receptors in Pleural Effusions from Septic and Nonseptic Patients Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1515 - 1522. [Abstract] [Full Text]
|
|
|
|
 |
|
 M.A. Tufano, P. Catalanotti, C. Capasso, P. De Paolis, M. Ranieri, and F. Rossano Compartmentalization of intravesical and systemic interleukin-6 and tumor necrosis factor {alpha} in mice stimulated with porins and lipopolysaccharide from Salmonella typhimurium Innate Immunity, October 1, 1995; 2(5): 359 - 364. [Abstract] [PDF]
|
|
|
|
 |
|
 C Graziosi, G Pantaleo, K. Gantt, J. Fortin, J. Demarest, O. Cohen, R. Sekaly, and A. Fauci Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals Science, July 8, 1994; 265(5169): 248 - 252. [Abstract] [PDF]
|
|
|
|
|
|
A. Fauci Multifactorial nature of human immunodeficiency virus disease: implications for therapy Science, November 12, 1993; 262(5136): 1011 - 1018. [Abstract] [PDF]
|
|
|
|
|
|
B. R. Bloom and C. J. L. Murray Tuberculosis: Commentary on a Reemergent Killer Science, August 21, 1992; 257(5073): 1055 - 1064. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
