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The Journal of Immunology, Vol 145, Issue 1 136-139, Copyright © 1990 by American Association of Immunologists

ARTICLES

T lymphocyte recognition of a celiac disease-associated cis- or trans- encoded HLA-DQ alpha/beta-heterodimer [published erratum appears in J Immunol 1990 Nov 1;145(9):3151]

KE Lundin, LM Sollid, E Qvigstad, G Markussen, HA Gjertsen, J Ek and E Thorsby
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.

The HLA-associated susceptibility to develop celiac disease may to a large extent be attributed to the combination of particular DQA1 and DQB1 genes, i.e., the DQA1*0501 and DBQB1*0201 alleles, located either in cis position (on the DR3DQw2 haplotype) or in trans position (DR5DQw7/DR7DQw2 heterozygous individuals). We report three alloreactive T lymphocyte clones that recognize an HLA-DQ alpha/beta heterodimer both when the DQA1*0501 and DQB1*0201 alleles are located in cis or in trans position. Thus, the celiac disease associated DQA1 and DQB1 genes encode a functionally expressed DQ alpha/beta heterodimer.




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