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The Journal of Immunology, Vol 144, Issue 6 2327-2333, Copyright © 1990 by American Association of Immunologists

ARTICLES

CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits

CM Doerschuk, RK Winn, HO Coxson and JM Harlan
University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, Canada.

Neutrophil (PMN) migration in the systemic and pulmonary circulation of rabbits was compared by using different inflammatory stimuli to determine the role of the leukocyte adhesion complex, CD11/CD18, in each of these vascular beds. The adhesion complex was blocked by administering the anti-CD18 mAb 60.3. The data show that mAb 60.3 blocks PMN emigration into inflammatory foci in the abdominal wall produced by implanting sponges containing either hydrochloric acid, Streptococcus pneumoniae, Escherichia coli endotoxin, or PMA. mAb 60.3 also inhibited PMN emigration in response to peritoneal instillation of S. pneumoniae. The effect of mAb 60.3 on PMN emigration in the lungs varied depending upon the stimulus. PMN failed to migrate into the PMA- induced pneumonia; however, mAb 60.3 pretreatment only partially inhibited endotoxin-induced pneumonia and did not inhibit S. pneumoniae or hydrochloric acid-induced pneumonias. PMN lavaged from the alveolar spaces in the Streptococcal pneumonia had similar quantities of mAb 60.3 bound to their surfaces as the circulating PMN. We conclude that the CD11/CD18 complex mediates PMN adherence in the systemic circulation. However, PMN adherence in the pulmonary circulation may occur by either CD18-dependent or -independent mechanisms that are specific to the inciting stimulus.


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T. Yamamoto, O. Kajikawa, T. R. Martin, S. R. Sharar, J. M. Harlan, and R. K. Winn2
The Role of Leukocyte Emigration and IL-8 on the Development of Lipopolysaccharide-Induced Lung Injury in Rabbits
J. Immunol., November 15, 1998; 161(10): 5704 - 5709.
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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S.-Z. Wang, P. K. Smith, M. Lovejoy, J. J. Bowden, J. H. Alpers, and K. D. Forsyth
Shedding of L-selectin and PECAM-1 and upregulation of Mac-1 and ICAM-1 on neutrophils in RSV bronchiolitis
Am J Physiol Lung Cell Mol Physiol, November 1, 1998; 275(5): L983 - L989.
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 Am. J. Respir. Cell Mol. Bio.Home page
H. M. DeLisser and S. M. Albelda
The Function of Cell Adhesion Molecules in Lung Inflammation: More Questions Than Answers
Am. J. Respir. Cell Mol. Biol., October 1, 1998; 19(4): 533 - 536.
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 BloodHome page
J. W. Homeister, M. Zhang, P. S. Frenette, R. O. Hynes, D. D. Wagner, J. B. Lowe, and R. M. Marks
Overlapping Functions of E- and P-Selectin in Neutrophil Recruitment During Acute Inflammation
Blood, October 1, 1998; 92(7): 2345 - 2352.
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 BloodHome page
S. Neelamegham, A. D. Taylor, A. R. Burns, C. W. Smith, and S. I. Simon
Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1
Blood, September 1, 1998; 92(5): 1626 - 1638.
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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Sato, S. F. Van Eeden, D. English, and J. C. Hogg
Pulmonary sequestration of polymorphonuclear leukocytes released from bone marrow in bacteremic infection
Am J Physiol Lung Cell Mol Physiol, August 1, 1998; 275(2): L255 - L261.
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 Infect. Immun.Home page
Y. Bergeron, N. Ouellet, A.-M. Deslauriers, M. Simard, M. Olivier, and M. G. Bergeron
Cytokine Kinetics and Other Host Factors in Response to Pneumococcal Pulmonary Infection in Mice
Infect. Immun., March 1, 1998; 66(3): 912 - 922.
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 Arch. Dis. Child. Fetal Neonatal Ed.Home page
S Kotecha, M Silverman, R J Shaw, and N Klein
Soluble L-selectin concentration in bronchoalveolar lavage fluid obtained from infants who develop chronic lung disease of prematurity
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 1998; 78(2): 143F - 147.
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 J. Immunol.Home page
X.-z. Shang, B. J. Lang, and A. C. Issekutz
Adhesion Molecule Mechanisms Mediating Monocyte Migration Through Synovial Fibroblast and Endothelium Barriers: Role for CD11/CD18, Very Late Antigen-4 (CD49d/CD29), Very Late Antigen-5 (CD49e/CD29), and Vascular Cell Adhesion Molecule-1 (CD106)
J. Immunol., January 1, 1998; 160(1): 467 - 474.
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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. P. Williams, M. R. Weiser, T. T. V. Pechet, L. Kobzik, F. D. Moore Jr., and H. B. Hechtman
alpha 1-Acid glycoprotein reduces local and remote injuries after intestinal ischemia in the rat
Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1031 - G1035.
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 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Aoki, Y. Suzuki, K. Nishio, K. Suzuki, A. Miyata, Y. Iigou, H. Serizawa, H. Tsumura, Y. Ishimura, M. Suematsu, et al.
Role of CD18-ICAM-1 in the entrapment of stimulated leukocytes in alveolar capillaries of perfused rat lungs
Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2361 - H2371.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
S. E. Malawista and A. d. B. Chevance
Random locomotion and chemotaxis of human blood polymorphonuclear leukocytes (PMN) in the presence of EDTA: PMN in close quarters require neither leukocyte integrins nor external divalent cations
PNAS, October 14, 1997; 94(21): 11577 - 11582.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
M. R. Weiser, T. T. V. Pechet, J. P. Williams, M. Ma, P. S. Frenette, F. D. Moore, L. Kobzik, R. O. Hines, D. D. Wagner, M. C. Carroll, et al.
Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway
J Appl Physiol, October 1, 1997; 83(4): 1090 - 1095.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
J. G. Filep, A. Delalandre, Y. Payette, and E. Foldes-Filep
Glucocorticoid Receptor Regulates Expression of L-Selectin and CD11/CD18 on Human Neutrophils
Circulation, July 1, 1997; 96(1): 295 - 301.
[Abstract] [Full Text]

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 J. Appl. Physiol.Home page
H. G. Folkesson and M. A. Matthay
Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits
J Appl Physiol, June 1, 1997; 82(6): 1743 - 1750.
[Abstract] [Full Text] [PDF]

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 BloodHome page
P. H. Reinhardt, J. F. Elliott, and P. Kubes
Neutrophils Can Adhere Via alpha 4beta 1 -Integrin Under Flow Conditions
Blood, May 15, 1997; 89(10): 3837 - 3846.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Crit. Care Med.Home page
K. NISHIO, Y. SUZUKI, T. AOKI, K. SUZUKI, A. MIYATA, N. SATO, K. NAOKI, H. KUDO, H. TSUMURA, H. SERIZAWA, et al.
Differential Contribution of Various Adhesion Molecules to Leukocyte Kinetics in Pulmonary Microvessels of Hyperoxia-exposed Rat Lungs
Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 599 - 609.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
Y. Naka, K. Toda, K. Kayano, M. C. Oz, and D. J. Pinsky
Failure to express the P-selectin gene or P-selectin blockade confers early pulmonary protection after lung ischemia or transplantation
PNAS, January 21, 1997; 94(2): 757 - 761.
[Abstract] [Full Text] [PDF]

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 JEMHome page
D. E. Morgenstern, M. A.C. Gifford, L. L. Li, C. M. Doerschuk, and M. C. Dinauer
Absence of Respiratory Burst in X-linked Chronic Granulomatous Disease Mice Leads to Abnormalities in Both Host Defense and Inflammatory Response to Aspergillus fumigatus
J. Exp. Med., January 20, 1997; 185(2): 207 - 218.
[Abstract] [Full Text] [PDF]

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 Mult SclerHome page
L M Rose, T L Richards, J Peterson, R Petersen, and E C Alvord Jr
Resolution of CNS lesions following treatment of experimental allergic encephalomyelitis in macaques with monoclonal antibody to the CD 18 leukocyte integrin
Multiple Sclerosis, January 1, 1997; 2(6): 259 - 266.
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 Ann. Thorac. Surg.Home page
D. D. Thomas, S. R. Sharar, R. K. Winn, E. Y. Chi, E. D. Verrier, M. D. Allen, and M. J. Bishop
CD18-Independent Mechanism of Neutrophil Emigration in the Rabbit Lung After Ischemia-Reperfusion
Ann. Thorac. Surg., November 1, 1995; 60(5): 1360 - 1366.
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 Ann. Thorac. Surg.Home page
K. Uthoff, K. J. Zehr, P. C. Lee, R. A. Low, W. A. Baumgartner, D. E. Cameron, and R. S. Stuart
Neutrophil Modulation Results in Improved Pulmonary Function After 12 and 24 Hours of Preservation
Ann. Thorac. Surg., January 1, 1995; 59(1): 7 - 13.
[Abstract] [Full Text]

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 Arch SurgHome page
S. Inoue, A. Nakao, W. Kishimoto, H. Murakami, K. Itoh, T. Itoh, A. Harada, T. Nonami, and H. Takagi
Anti-Neutrophil Antibody Attenuates the Severity of Acute Lung Injury in Rats With Experimental Acute Pancreatitis
Arch Surg, January 1, 1995; 130(1): 93 - 98.
[Abstract] [PDF]

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 Arch SurgHome page
T. P. Connall, J. Zhang, N. D. Vaziri, R. J. Schwartz, C. J. Kaupke, F. Oveisi, and S. E. Wilson
Radiodetoxified Endotoxin--Induced Tolerance Alters Monocyte but Not Neutrophil CD11b and CD18 Expression in Response to Lipopolysaccharide
Arch Surg, November 1, 1994; 129(11): 1153 - 1158.
[Abstract] [PDF]

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 PerfusionHome page
H. Komai and S. G Haworth
The effect of cardiopulmonary bypass on the lung: the injured pulmonary vascular endothelium
Perfusion, January 1, 1993; 8(1): 55 - 62.
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 ANN INTERN MEDHome page
S. R. Frankel, A. Eardley, G. Lauwers, M. Weiss, and R. P. Warrell Jr.
The "Retinoic Acid Syndrome" in Acute Promyelocytic Leukemia
Ann Intern Med, August 15, 1992; 117(4): 292 - 296.
[Abstract] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. S. Olson, K. Singbartl, and K. Ley
L-selectin is required for fMLP- but not C5a-induced margination of neutrophils in pulmonary circulation
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1245 - R1252.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
R. A. Bowden, Z.-M. Ding, E. M. Donnachie, T. K. Petersen, L. H. Michael, C. M. Ballantyne, and A. R. Burns
Role of {alpha}4 Integrin and VCAM-1 in CD18-Independent Neutrophil Migration Across Mouse Cardiac Endothelium
Circ. Res., March 22, 2002; 90(5): 562 - 569.
[Abstract] [Full Text] [PDF]


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