| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 144, Issue 11 4226-4230, Copyright © 1990 by American Association of Immunologists
ARTICLES |
N Kurihara, D Bertolini, T Suda, Y Akiyama and GD Roodman
Research Service, Audie Murphy VA Hospital, San Antonio, TX 78284.
IL-6 enhances the differentiation of pluripotent hematopoietic stem cells but predominantly affects the differentiation of hematopoietic cells in the granulocyte-macrophage lineage. We have previously shown that multinucleated cells (MNC) with many features of the osteoclast phenotype form in long term human marrow cultures. Addition of rhIL-6 (10 to 100 pg/ml) to these cultures significantly increased MNC formation, with greater than 80% of the MNC expressing an Ag that cross- reacts with the mAb 23c6. This antibody preferentially binds to osteoclasts. rhIL-6 did not enhance MNC formation in marrow cultures treated with 1,25 dihydroxyvitamin D3, a potent stimulator of MNC formation, but significantly increased the percentage of MNC that cross- reacted with the 23c6 mAb. Addition of antihuman IL-1 to cultures treated with rhIL-6 totally inhibited the increase in MNC formation stimulated by rhIL-6. In contrast, anti-IL-1 did not affect MNC formation stimulated by 1,25 dihydroxyvitamin D3. Further, conditioned media from marrow cultures exposed to rhIL-6 contained elevated levels of IL-1 beta (500 pg/ml compared to 23 pg/ml in control cultures 15 h after IL-6 addition). These results suggest that the capacity of rhIL-6 to stimulate formation of MNC which cross-react with 23c6 is mediated by induction of release of IL-1 beta.
This article has been cited by other articles:
|
|
 |
|
  C.-H. Tang, J.-Y. Chuang, Y.-C. Fong, M.-C. Maa, T.-D. Way, and C.-H. Hung Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-{kappa}B pathways and promotes osteoclastogenesis in human oral cancer cells Carcinogenesis, August 1, 2008; 29(8): 1483 - 1492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Tanabe, C. Bodet, and D. Grenier Peptostreptococcus micros cell wall elicits a pro-inflammatory response in human macrophages Innate Immunity, August 1, 2007; 13(4): 219 - 226. [Abstract] [PDF]
|
|
|
|
 |
|
 B J M Ripley, B Goncalves, D A Isenberg, D S Latchman, and A Rahman Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia Ann Rheum Dis, June 1, 2005; 64(6): 849 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tolar, S. L. Teitelbaum, and P. J. Orchard Osteopetrosis N. Engl. J. Med., December 30, 2004; 351(27): 2839 - 2849. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tanaka, T. Morita, A. Nezu, A. Tanimura, I. Mizoguchi, and Y. Tojyo Signaling Mechanisms Involved in Protease-Activated Receptor-1-Mediated Interleukin-6 Production by Human Gingival Fibroblasts J. Pharmacol. Exp. Ther., November 1, 2004; 311(2): 778 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Roodman Mechanisms of Bone Metastasis N. Engl. J. Med., April 15, 2004; 350(16): 1655 - 1664. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Trikha, R. Corringham, B. Klein, and J.-F. Rossi Targeted Anti-Interleukin-6 Monoclonal Antibody Therapy for Cancer: A Review of the Rationale and Clinical Evidence Clin. Cancer Res., October 15, 2003; 9(13): 4653 - 4665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Okada, A. Montero, X. Zhang, T. Sobue, J. Lorenzo, T. Doetschman, J. D. Coffin, and M. M. Hurley Impaired Osteoclast Formation in Bone Marrow Cultures of Fgf2 Null Mice in Response to Parathyroid Hormone J. Biol. Chem., May 30, 2003; 278(23): 21258 - 21266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kagari, H. Doi, and T. Shimozato The Importance of IL-1{beta} and TNF-{alpha}, and the Noninvolvement of IL-6, in the Development of Monoclonal Antibody-Induced Arthritis J. Immunol., August 1, 2002; 169(3): 1459 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.D. Neale, E. Schulze, R. Smith, and N.A. Athanasou The influence of serum cytokines and growth factors on osteoclast formation in Paget's disease QJM, April 1, 2002; 95(4): 233 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz Changes in Proinflammatory Cytokine Activity after Menopause Endocr. Rev., February 1, 2002; 23(1): 90 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lourbakos, J. Potempa, J. Travis, M. R. D'Andrea, P. Andrade-Gordon, R. Santulli, E. J. Mackie, and R. N. Pike Arginine-Specific Protease from Porphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion Infect. Immun., August 1, 2001; 69(8): 5121 - 5130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Roodman Biology of Osteoclast Activation in Cancer J. Clin. Oncol., August 1, 2001; 19(15): 3562 - 3571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Han, S. J. Choi, N. Kurihara, M. Koide, Y. Oba, and G. D. Roodman Macrophage inflammatory protein-1{alpha} is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor {kappa}B ligand Blood, June 1, 2001; 97(11): 3349 - 3353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshii, H. Nishimura, T. Yoshikawa, S. Furudoi, A. Yoshioka, I. Takenono, Y. Ohtsuka, and T. Komori Therapeutic possibilities of long-term roxithromycin treatment for chronic diffuse sclerosing osteomyelitis of the mandible J. Antimicrob. Chemother., May 1, 2001; 47(5): 631 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mittelman, D. Neumann, A. Peled, P. Kanter, and N. Haran-Ghera Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models PNAS, April 12, 2001; (2001) 81275298. [Abstract] [Full Text]
|
|
|
|
|
|
K. Balto, H. Sasaki, and P. Stashenko Interleukin-6 Deficiency Increases Inflammatory Bone Destruction Infect. Immun., February 1, 2001; 69(2): 744 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Choi, J. C. Cruz, F. Craig, H. Chung, R. D. Devlin, G. D. Roodman, and M. Alsina Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma Blood, July 15, 2000; 96(2): 671 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Anderson, V. L. Shires, R. Alan Wilson, and A. P. Mountford Formation of Multinucleated Giant Cells in the Mouse Lung Is Promoted in the Absence of Interleukin-12 Am. J. Respir. Cell Mol. Biol., March 1, 1999; 20(3): 371 - 378. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Frost, K. B. Jonsson, H. Brändström, C. Ohlsson, S. Ljunghall, and O. Ljunggren Interleukin-13 Inhibits Cell Proliferation and Stimulates Interleukin-6 Formation in Isolated Human Osteoblasts J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3285 - 3289. [Abstract] [Full Text]
|
|
|
|
|
|
D. Cheleuitte, S. Mizuno, and J. Glowacki In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2043 - 2051. [Abstract] [Full Text]
|
|
|
|
|
|
K. Ziambaras, W. A. Totty, S. L. Teitelbaum, M. Dierkes, and M. P. Whyte Extraskeletal Osteoclastomas Responsive to Dexamethasone Treatment in Paget Bone Disease J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3826 - 3834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lakatos, J. Foldes, C. Horvath, L. Kiss, A. Tatrai, I. Takacs, G. Tarjan, and P. H. Stern Serum Interleukin-6 and Bone Metabolism in Patients with Thyroid Function Disorders J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 78 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mittelman, D. Neumann, A. Peled, P. Kanter, and N. Haran-Ghera Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models PNAS, April 24, 2001; 98(9): 5181 - 5186. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
