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The Journal of Immunology, Vol 144, Issue 11 4177-4182, Copyright © 1990 by American Association of Immunologists

ARTICLES

Identification of a single non-H-2 gene regulating graft-versus-host disease response

LD Fast
Department of Medicine, Rhode Island Hospital, Providence 02903.

Non-MHC loci have been shown to play an important role in the development and regulation of graft-vs-host disease (GVHD). In the murine model of GVHD under study, injection of C57BL/6 spleen cells into unirradiated (C57BL/6 x DBA/2)F1 hybrid recipient mice results in an acute form of GVHD characterized by CTL, suppressor cells, and runting. In contrast, injection of DBA/2 spleen cells into the same recipients results in a chronic form of GVHD that is characterized by a lack of CTL and hyperproduction of Ig and autoantibodies. After preliminary studies with the use of congenic mice showed that non-MHC loci were controlling GVHD responses in this model, genetic analysis of GVHD response of BXD recombinant inbred strains and (B10.D2 x DBA/2) X DBA/2 BC mice identified a single locus, Gvh, on chromosome 7 that controls whether acute or chronic GVHD results from injection of parental lymphocytes into unirradiated (C57BL/6 x DBA/2)F1 recipient mice.


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S. P. Murphy, L. D. Fast, N. N. Hanna, and S. Sharma
Uterine NK Cells Mediate Inflammation-Induced Fetal Demise in IL-10-Null Mice
J. Immunol., September 15, 2005; 175(6): 4084 - 4090.
[Abstract] [Full Text] [PDF]


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