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The Journal of Immunology, Vol 143, Issue 3 864-869, Copyright © 1989 by American Association of Immunologists
ARTICLES |
JY Bonnefoy, MC Denoroy, O Guillot, CL Martens and J Banchereau
UNICET, Laboratory for Immunological Research, Dardilly, France.
We studied whether normal human B cells would express IL-1 activity and transcribe IL-1 genes before or after activation through their Ag receptor. Anti IgM antibody-activated B cells expressed IL-1 alpha on the cell surface and secreted IL-1 beta. Optimal induction of IL-1 occurred within 16 h of anti-IgM activation. mRNA specific for both IL- 1 alpha and IL-1 beta was also induced upon activation. It is likely that the expression of m-IL-1 alpha on activated B cells together with the secretion of IL-1 beta represent important contributions in the efficient Ag-presenting capacity of B cells to T cells.
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