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The Journal of Immunology, Vol 143, Issue 3 1015-1017, Copyright © 1989 by American Association of Immunologists

ARTICLES

Somatostatin gene expression in the thymus gland

PJ Fuller and K Verity
Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia.

A complex pattern of interactions appears to exist between the immune and neuroendocrine systems. Recently, vasopressin, oxytocin and vasoactive intestinal peptide have been isolated from the thymus. Using a rat somatostatin antisense RNA probe we have demonstrated expression of the somatostatin gene in the rat thymus. Furthermore, we have shown that the levels of thymic somatostatin mRNA exhibit a bell-shaped response to dexamethasone administration. Lipocortin I and II antisense RNA probes have been used as a positive control for the effects of the dexamethasone. We would suggest that somatostatin acts in the thymus in a paracrine mode to modulate T lymphocyte development.


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