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The Journal of Immunology, Vol 143, Issue 2 513-517, Copyright © 1989 by American Association of Immunologists

ARTICLES

IL-1 induces high affinity IL-2 receptor expression of CD4-8- thymocytes

W Falk, DN Mannel, H Darjes and PH Krammer
Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg.

We investigated the role of cytokines for the growth of CD4-8- thymocytes (double negative thymocytes) (DNT) in vitro and found that IL-1-induced IL-2-dependent proliferation of only the IL-2R-positive DNT subpopulation. The presence of IL-1 during the first 18 h of culture was sufficient for an optimal response and suggested that IL-1 induced DNT differentiation. We could indeed show by RNA dot blot analysis that IL-1 stimulated de novo expression of the p55 chain of the IL-2R thus initiating high affinity IL-2 binding and a proliferative response. Because macrophages and epithelial cells in the thymus produce IL-1 we propose that IL-1 is involved in early events during maturation of immature thymocytes.




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