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The Journal of Immunology, Vol 143, Issue 11 3653-3658, Copyright © 1989 by American Association of Immunologists

ARTICLES

Phorbol esters regulate CD2- and CD3-mediated calcium responses in peripheral blood-derived human T cells

DA Cantrell, SC Lucas, S Ward, J Westwick and M Gullberg
Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London, UK.

The purpose of the present study was to examine the effect of protein kinase C (pkC) activation on calcium responses generated through the CD3 and CD2 Ag in both normal peripheral blood-derived T lymphocytes and the leukemic T cell line Jurkat. The data reveal a major difference with respect to the regulation of receptor-mediated calcium responses in these two cells. Thus, the pkC activator phorbol-12,13-dibutyrate (Pdbu) enhances calcium responses induced via CD3 and CD2 molecules in normal T cells by accelerating the rate of elevation of intracellular calcium levels and increasing the maximum change in calcium concentration achieved. In contrast, Pdbu inhibits both CD3- and CD2- induced calcium responses in Jurkat cells. Pdbu does not influence calcium responses generated by the guanine nucleotide-binding protein activator, aluminium fluoride, indicating that the effect of pkC occurs at a point proximal to a guanine nucleotide-binding protein regulation of T cell calcium responses.


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