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The Journal of Immunology, Vol 142, Issue 8 2736-2742, Copyright © 1989 by American Association of Immunologists

ARTICLES

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors

RT Kubo, W Born, JW Kappler, P Marrack and M Pigeon
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

Research on the specificities, functions, and maturation of T cells would be greatly aided by a collection of monoclonal antibodies which distinguishes different types of TCR. With this end in mind hamsters were immunized and tested for production of pan-reactive anti-mouse alpha beta TCR antibodies. In this report we describe the properties and uses of a mAb, H57-597, produced from one of these animals. The mAb reacts with surface receptors on all alpha beta TCR-bearing cells and does not react with receptors on gamma delta+ T cells. In an immobilized form, this antibody can directly activate T cells bearing alpha beta TCR. It can be used in immunoprecipitation reactions to precipitate receptor from the appropriate cell types. In combination with anti-CD3, the antibody can be used in cytofluorographic analyses to measure numbers of CD3+, alpha beta+, and CD3+, gamma delta+ cells in the thymus and periphery.


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 Int ImmunolHome page
R. J. Hayashi and O. Kanagawa
Unique CD4+ T cells in TCR {alpha} chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process
Int. Immunol., September 1, 1999; 11(9): 1581 - 1590.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. Carleton, N. R. Ruetsch, M. A. Berger, M. Rhodes, S. Kaptik, and D. L. Wiest
Signals Transduced by CD3{epsilon}, But Not by Surface Pre-TCR Complexes, Are Able to Induce Maturation of an Early Thymic Lymphoma In Vitro
J. Immunol., September 1, 1999; 163(5): 2576 - 2585.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
S. Marschner, B. A. Freiberg, A. Kupfer, T. Hunig, and T. H. Finkel
Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin
PNAS, August 17, 1999; 96(17): 9763 - 9768.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
W. Rees, J. Bender, T. K. Teague, R. M. Kedl, F. Crawford, P. Marrack, and J. Kappler
An inverse relationship between T cell receptor affinity and antigen dose during CD4+ T cell responses in vivo and in vitro
PNAS, August 17, 1999; 96(17): 9781 - 9786.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
B. L. Leung, L. Haughn, A. Veillette, R. G. Hawley, R. Rottapel, and M. Julius
TCR{alpha}{beta}-Independent CD28 Signaling and Costimulation Require Non-CD4-Associated Lck
J. Immunol., August 1, 1999; 163(3): 1334 - 1341.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. A. Coppola, E. Flano, P. Nguyen, C. L. Hardy, R. D. Cardin, N. Shastri, D. L. Woodland, and M. A. Blackman
Apparent MHC-Independent Stimulation of CD8+ T Cells In Vivo During Latent Murine Gammaherpesvirus Infection
J. Immunol., August 1, 1999; 163(3): 1481 - 1489.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
L. Liu, E. Flano, E. J. Usherwood, S. Surman, M. A. Blackman, and D. L. Woodland
Lytic Cycle T Cell Epitopes Are Expressed in Two Distinct Phases During MHV-68 Infection
J. Immunol., July 15, 1999; 163(2): 868 - 874.
[Abstract] [Full Text] [PDF]

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 JEMHome page
C. Miller, J. A. Ragheb, and R. H. Schwartz
Anergy and Cytokine-Mediated Suppression as Distinct Superantigen-Induced Tolerance Mechanisms in Vivo
J. Exp. Med., July 1, 1999; 190(1): 53 - 64.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. A. Ragheb, M. Deen, and R. H. Schwartz
CD28-Mediated Regulation of mRNA Stability Requires Sequences Within the Coding Region of the IL-2 mRNA
J. Immunol., July 1, 1999; 163(1): 120 - 129.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. Antica and R. Scollay
Development of T Lymphocytes at Extrathymic Sites
J. Immunol., July 1, 1999; 163(1): 206 - 211.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
C. A. Yiamouyiannis, C. M. Schramm, L. Puddington, P. Stengel, E. Baradaran-Hosseini, W. W. Wolyniec, H. E. Whiteley, and R. S. Thrall
Shifts in Lung Lymphocyte Profiles Correlate with the Sequential Development of Acute Allergic and Chronic Tolerant Stages in a Murine Asthma Model
Am. J. Pathol., June 1, 1999; 154(6): 1911 - 1921.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. Matsuo, H. Wada, S. Honda, I. Tawara, A. Uenaka, T. Kanematsu, and E. Nakayama
Expression of Multiple Unique Rejection Antigens on Murine Leukemia BALB/c RL[IMAGE]1 and the Role of Dominant Akt Antigen for Tumor Escape
J. Immunol., June 1, 1999; 162(11): 6420 - 6425.
[Abstract] [Full Text] [PDF]

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 JEMHome page
S. Degermann, G. Sollami, and K. Karjalainen
T Cell Receptor {beta} Chain Lacking the Large Solvent-exposed C{beta} FG Loop Supports Normal {alpha}/{beta} T Cell Development and Function in Transgenic Mice
J. Exp. Med., May 17, 1999; 189(10): 1679 - 1684.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. G. Gardner and K. P. Kearse
Modification of the T Cell Antigen Receptor (TCR) Complex by UDP-glucose:Glycoprotein Glucosyltransferase. TCR FOLDING IS FINALIZED CONVERGENT WITH FORMATION OF alpha beta delta epsilon gamma epsilon COMPLEXES
J. Biol. Chem., May 14, 1999; 274(20): 14094 - 14099.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
L. Majlessi and G. Bordenave
Evidence of Alternative or Concomitant Use of Perforin- and Fas-Dependent Pathways in a T Cell-Mediated Negative Regulation of Ig Production
J. Immunol., April 15, 1999; 162(8): 4391 - 4398.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
P. Riegert and S. Gilfillan
A Conserved Sequence Block in the Murine and Human TCR J{alpha} Region: Assessment of Regulatory Function In Vivo
J. Immunol., March 15, 1999; 162(6): 3471 - 3480.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. White, F. Crawford, D. Fremont, P. Marrack, and J. Kappler
Soluble Class I MHC with {beta}2-Microglobulin Covalently Linked Peptides: Specific Binding to a T Cell Hybridoma
J. Immunol., March 1, 1999; 162(5): 2671 - 2676.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. D. Powell, C. G. Lerner, and R. H. Schwartz
Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation
J. Immunol., March 1, 1999; 162(5): 2775 - 2784.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
C.-L. Chu, S.-S. Chen, T.-S. Wu, S.-C. Kuo, and N.-S. Liao
Differential Effects of IL-2 and IL-15 on the Death and Survival of Activated TCR{gamma}{delta}+ Intestinal Intraepithelial Lymphocytes
J. Immunol., February 15, 1999; 162(4): 1896 - 1903.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
T. B. Oriss, S. A. McCarthy, M. A. K. Campana, and P. A. Morel
Evidence of Positive Cross-Regulation on Th1 by Th2 and Antigen-Presenting Cells: Effects on Th1 Induced by IL-4 and IL-12
J. Immunol., February 15, 1999; 162(4): 1999 - 2007.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
M. Yamashita, M. Kimura, M. Kubo, C. Shimizu, T. Tada, R. M. Perlmutter, and T. Nakayama
T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation
PNAS, February 2, 1999; 96(3): 1024 - 1029.
[Abstract] [Full Text] [PDF]

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 JEMHome page
J. P. Di Santo, I. Aifantis, E. Rosmaraki, C. Garcia, J. Feinberg, H. J. Fehling, A. Fischer, H. von Boehmer, and B. Rocha
The Common Cytokine Receptor {gamma} Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early {alpha}/{beta} T Cell Development
J. Exp. Med., February 1, 1999; 189(3): 563 - 574.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. Bonnard, L. Haughn, and M. Julius
CD4-Mediated Inhibiton of IL-2 Production in Activated T Cells
J. Immunol., February 1, 1999; 162(3): 1252 - 1260.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
G. N. R. Vespa, L. A. Lewis, K. R. Kozak, M. Moran, J. T. Nguyen, L. G. Baum, and M. C. Miceli
Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation
J. Immunol., January 15, 1999; 162(2): 799 - 806.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
C. Bonorino, N. B. Nardi, X. Zhang, and L. J. Wysocki
Characteristics of the Strong Antibody Response to Mycobacterial Hsp70: A Primary, T Cell-Dependent IgG Response with no Evidence of Natural Priming or {gamma}{delta} T Cell Involvement
J. Immunol., November 15, 1998; 161(10): 5210 - 5216.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
K. Lingnau, P. Hoehn, S. Kerdine, S. Koelsch, C. Neudoerfl, N. Palm, E. Ruede, and E. Schmitt
IL-4 in Combination with TGF-{beta} Favors an Alternative Pathway of Th1 Development Independent of IL-12
J. Immunol., November 1, 1998; 161(9): 4709 - 4718.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. W. Schilham, A. Wilson, P. Moerer, B. J. Benaissa-Trouw, A. Cumano, and H. C. Clevers
Critical Involvement of Tcf-1 in Expansion of Thymocytes
J. Immunol., October 15, 1998; 161(8): 3984 - 3991.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
B. K. al-Ramadi, H. Zhang, and A. L. M. Bothwell
Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytes
PNAS, October 13, 1998; 95(21): 12498 - 12503.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. J. Bennett, J. E. M. Van Leeuwen, and K. P. Kearse
Calnexin Association Is Not Sufficient to Protect T Cell Receptor alpha  Proteins from Rapid Degradation in CD4+CD8+ Thymocytes
J. Biol. Chem., September 11, 1998; 273(37): 23674 - 23680.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. Q. Russell, T. Mooney, P. L. Cohen, B. MacPherson, R. J. Noelle, and R. C. Budd
Anti-CD40L Accelerates Renal Disease and Adenopathy in MRL-lpr Mice in Parallel with Decreased Thymocyte Apoptosis
J. Immunol., July 15, 1998; 161(2): 729 - 739.
[Abstract] [Full Text] [PDF]


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