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The Journal of Immunology, Vol 142, Issue 6 1834-1839, Copyright © 1989 by American Association of Immunologists

ARTICLES

Macrophage factors which enhance the mixed leukocyte reaction initiated by dendritic cells

K Naito, K Inaba, Y Hirayama, M Inaba-Miyama, T Sudo and S Muramatsu
Department of Zoology, Faculty of Science, Kyoto University, Japan.

Stimulator cells for the allogeneic MLR are dendritic cells but not macrophages (M phi). M phi, however, enhance the MLR initiated by relatively low doses of dendritic cells. The present report demonstrates that the enhancement of the MLR is mediated by two factors produced by M phi. One is IL-1, inasmuch as it has a Mr approximately 15 kDa, and both partially purified IL-1 and rIL-1 also enhance the MLR. The other has been identified as granulocyte-macrophage (GM)-CSF. It had a Mr approximately 25 kDa, and is reproduced by rGM-CSF. Moreover, the MLR-enhancing activity of both the 25-kDa molecule and rGM-CSF have been neutralized by anti-GM-CSF antiserum. Both IL-1 and GM-CSF have autonomous enhancing activity, but they collaborate with each other in enhancing the MLR. Both factors act on DC to augment their stimulatory activity for allogeneic T lymphocytes.


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