The Journal of Immunology, Vol 142, Issue 4 1095-1101, Copyright © 1989 by American Association of Immunologists

ARTICLES

Regulation of B lymphocytes by natural killer cells. Role of IFN-gamma

A Michael, JJ Hackett, M Bennett, V Kumar and D Yuan
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.

Using a co-culture system of fractionated B cells and highly purified NK cells, we have demonstrated direct interactions between B lymphocytes and NK cells. B cells are able to stimulate the production of IFN-gamma by NK cells. This stimulatory ability is restricted to a subpopulation of large, presumably in vivo activated B lymphocytes. The secreted IFN-gamma in turn inhibits polyclonally induced B cell proliferation. Small resting B cells neither stimulate IFN-gamma production nor are they measurably affected by NK cells.

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