The Journal of Immunology, Vol 142, Issue 3 927-931, Copyright © 1989 by American Association of Immunologists

ARTICLES

Substance P induces granulocyte infiltration through degranulation of mast cells

H Matsuda, K Kawakita, Y Kiso, T Nakano and Y Kitamura
Department of Veterinary Surgery, College of Agriculture, University of Osaka Prefecture, Japan.

Substance P, a potent vasodilatory neuropeptide, is released from peripheral nerve endings of sensory neurons by various stimuli. Although in vitro incubation of rat and human mast cells with substance P causes their degranulation, it is not known whether inflammatory changes induced by substance P are mediated by degranulation of mast cells. We investigated this point by using genetically mast cell- deficient WBB6F1-W/Wv and WCB6F1-Sl/Sld mice. The s.c. injection of substance P induced degranulation of mast cells in the skin of WBB6F1- +/+ mice, and then a marked eosinophil infiltration around the degranulated mast cells. However, WBB6F1-W/Wv and WCB6F1-Sl/Sld mice showed little or no eosinophil infiltration in the skin after the injection of substance P. When the mast cell deficiency of WBB6F1-W/Wv mice was rescued either systemically by bone marrow transplantation or locally by injection of cultured mast cells, injection of substance P induced the infiltration of eosinophils, suggesting that substance P- induced eosinophil infiltration was mediated through degranulation of mast cells.

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