The Journal of Immunology, Vol 142, Issue 3 781-784, Copyright © 1989 by American Association of Immunologists

ARTICLES

Genetic control of diabetes and insulitis in the nonobese diabetic mouse. Pedigree analysis of a diabetic H-2nod/b heterozygote

LS Wicker, BJ Miller, PA Fischer, A Pressey and LB Peterson
Department of Immunology Research, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.

The development of autoimmune type 1 diabetes mellitus in man and the nonobese diabetic (NOD) mouse is greatly influenced by a gene linked to the MHC. Although homozygosity at the NOD MHC is required for a high prevalence of disease, during backcross studies we have found a small number of diabetic H-2nod/b MHC heterozygotes. These diabetic heterozygotes could either represent a crossover event between the MHC and a putative MHC-linked diabetogenic gene or, alternatively, they could indicate that there is a dominant MHC-linked diabetic gene that has low penetrance in the heterozygous state. Pedigree analysis of a diabetic H-2nod/b MHC heterozygote favors the latter hypothesis.

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