| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 142, Issue 2 452-462, Copyright © 1989 by American Association of Immunologists
ARTICLES |
A Hoffenbach, P Langlade-Demoyen, G Dadaglio, E Vilmer, F Michel, C Mayaud, B Autran and F Plata
Laboratoire de Biologie et d'Immunologie Moleculaires des Retrovirus, Institut Pasteur, Paris, France.
CTL specific for the HIV belong to the CD8 subset of T lymphocytes, and their activity is restricted by class I HLA transplantation Ag. In this report, HIV-specific CTL and their precursor cells were quantified by limiting dilution analysis. CTL were recovered from the lungs, lymph nodes, and blood of asymptomatic seropositive carriers and of patients with AIDS. HIV was found to be very immunogenic. High frequencies of both HIV-specific CTL and CTL precursor cells were detected in infected individuals. These CTL killed autologous HIV-infected macrophages and T4 lymphoblasts. They also killed doubly transfected P815-A2-env-LAV mouse tumor cells, which express the human HLA-A2 gene and the HIV-1 env gene. In the longitudinal studies of two HIV-infected patients, CTL and CTL precursor cell frequencies decreased as the clinical and immunologic status of the patients deteriorated. Most surprisingly, PBL from seronegative donors also responded to HIV stimulation in vitro and generated large numbers of HLA-restricted, HIV-specific CTL.
This article has been cited by other articles:
|
|
 |
|
  A. Cochrane, S. Imlach, C. Leen, G. Scott, D. Kennedy, and P. Simmonds High Levels of Human Immunodeficiency Virus Infection of CD8 Lymphocytes Expressing CD4 In Vivo J. Virol., September 15, 2004; 78(18): 9862 - 9871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakaya, T. Nakaya, M.-S. Park, J. Cros, J. Imanishi, P. Palese, and A. Garcia-Sastre Induction of Cellular Immune Responses to Simian Immunodeficiency Virus Gag by Two Recombinant Negative-Strand RNA Virus Vectors J. Virol., September 1, 2004; 78(17): 9366 - 9375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lieberman, P. Shankar, N. Manjunath, and J. Andersson Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection Blood, September 15, 2001; 98(6): 1667 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fayolle, A. Osickova, R. Osicka, T. Henry, M.-J. Rojas, M.-F. Saron, P. Sebo, and C. Leclerc Delivery of Multiple Epitopes by Recombinant Detoxified Adenylate Cyclase of Bordetella pertussis Induces Protective Antiviral Immunity J. Virol., August 15, 2001; 75(16): 7330 - 7338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chen, P. Shankar, C. Lange, H. Valdez, P. R. Skolnik, L. Wu, N. Manjunath, and J. Lieberman CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection Blood, July 1, 2001; 98(1): 156 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Trimble, P. Shankar, M. Patterson, J. P. Daily, and J. Lieberman Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3zeta and CD28, Key Signaling Molecules for T-Cell Activation J. Virol., August 15, 2000; 74(16): 7320 - 7330. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Mollet, T.-S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran Dynamics of HIV-Specific CD8+ T Lymphocytes with Changes in Viral Load J. Immunol., August 1, 2000; 165(3): 1692 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sedlik, G. Dadaglio, M. F. Saron, E. Deriaud, M. Rojas, S. I. Casal, and C. Leclerc In Vivo Induction of a High-Avidity, High-Frequency Cytotoxic T-Lymphocyte Response Is Associated with Antiviral Protective Immunity J. Virol., July 1, 2000; 74(13): 5769 - 5775. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. L. Whiteside Monitoring of Antigen-Specific Cytolytic T Lymphocytes in Cancer Patients Receiving Immunotherapy Clin. Vaccine Immunol., May 1, 2000; 7(3): 327 - 332. [Full Text] [PDF]
|
|
|
|
|
|
P. L. Sharma and C. S. Crumpacker Decreased Processivity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Containing Didanosine-Selected Mutation Leu74Val: a Comparative Analysis of RT Variants Leu74Val and Lamivudine-Selected Met184Val J. Virol., October 1, 1999; 73(10): 8448 - 8456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dalod, M. Dupuis, J.-C. Deschemin, D. Sicard, D. Salmon, J.-F. Delfraissy, A. Venet, M. Sinet, and J.-G. Guillet Broad, Intense Anti-Human Immunodeficiency Virus (HIV) Ex Vivo CD8+ Responses in HIV Type 1-Infected Patients: Comparison with Anti-Epstein-Barr Virus Responses and Changes during Antiretroviral Therapy J. Virol., September 1, 1999; 73(9): 7108 - 7116. [Abstract] [Full Text]
|
|
|
|
|
|
R. Wagner, B. Leschonsky, E. Harrer, C. Paulus, C. Weber, B. D. Walker, S. Buchbinder, H. Wolf, J. R. Kalden, and T. Harrer Molecular and Functional Analysis of a Conserved CTL Epitope in HIV-1 p24 Recognized from a Long-Term Nonprogressor: Constraints on Immune Escape Associated with Targeting a Sequence Essential for Viral Replication J. Immunol., March 15, 1999; 162(6): 3727 - 3734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Alexander-Miller, M. A. Derby, A. Sarin, P. A. Henkart, and J. A. Berzofsky Supraoptimal Peptide-Major Histocompatibility Complex Causes a Decrease in Bcl-2 Levels and Allows Tumor Necrosis Factor alpha Receptor II-mediated Apoptosis of Cytotoxic T Lymphocytes J. Exp. Med., October 19, 1998; 188(8): 1391 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D.K. Wilson, G. S. Ogg, R. L. Allen, P. J.R. Goulder, A. Kelleher, A. K. Sewell, C. A. O'Callaghan, S. L. Rowland-Jones, M. F.C. Callan, and A. J. McMichael Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific J. Exp. Med., August 17, 1998; 188(4): 785 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hadida, V. Vieillard, B. Autran, I. Clark-Lewis, M. Baggiolini, and P. Debre HIV-specific T Cell Cytotoxicity Mediated by RANTES Via the Chemokine Receptor CCR3 J. Exp. Med., August 3, 1998; 188(3): 609 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Frenkel, J. I. Mullins, G. H. Learn, L. Manns-Arcuino, B. L. Herring, M. L. Kalish, R. W. Steketee, D. M. Thea, J. E. Nichols, S. Liu, et al. Genetic Evaluation of Suspected Cases of Transient HIV-1 Infection of Infants Science, May 15, 1998; 280(5366): 1073 - 1077. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Flamand, R. W. Crowley, P. Lusso, S. Colombini-Hatch, D. M. Margolis, and R. C. Gallo Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: Implications for HIV pathogenesis PNAS, March 17, 1998; 95(6): 3111 - 3116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Trimble and J. Lieberman Circulating CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Individuals Have Impaired Function and Downmodulate CD3zeta , the Signaling Chain of the T-Cell Receptor Complex Blood, January 15, 1998; 91(2): 585 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matano, R. Shibata, C. Siemon, M. Connors, H. C. Lane, and M. A. Martin Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/Human Immunodeficiency Virus during Primary Infections of Rhesus Macaques J. Virol., January 1, 1998; 72(1): 164 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lieberman, P. R. Skolnik, G. R. Parkerson III, J. A. Fabry, B. Landry, J. Bethel, J. Kagan, and the DATRI 006 Study Team Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients Blood, September 15, 1997; 90(6): 2196 - 2206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Altman, P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis Phenotypic Analysis of Antigen-Specific T Lymphocytes Science, October 4, 1996; 274(5284): 94 - 96. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
