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The Journal of Immunology, Vol 142, Issue 12 4335-4338, Copyright © 1989 by American Association of Immunologists
ARTICLES |
M Helle, L Boeije and LA Aarden
Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Both IL-1 and IL-6 have been shown to be comitogenic for lectin- stimulated thymocytes. Thymocytes cultured in the presence of IL-1 produce IL-6 themselves. This IL-6 production is caused by a cell population with low buoyant density. After removal of these cells, IL-6 or IL-2 are still co-mitogenic for thymocytes whereas IL-1 is not. Addition of IL-1 to such thymocytes renders them about 100-fold more sensitive to IL-6. At all conditions proliferation is inhibitable with antibodies to IL-2 and to the IL-2R. Our experiments show that IL-1- driven proliferation of thymocytes is dependent on endogenous IL-6 production and that in the classical thymocyte assay IL-1 has a dual role: it induces IL-6 production and it greatly increases the sensitivity for IL-6.
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