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The Journal of Immunology, Vol 141, Issue 9 3078-3080, Copyright © 1988 by American Association of Immunologists

ARTICLES

IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis

M Didier, C Aussel, C Pelassy and M Fehlmann
INSERM U210, Faculte de Medecine (Pasteur), Nice, France.

Activation of Jurkat T cells with anti-TCR, anti-CD3, anti-CD2, or PHA is accompanied by a strong inhibition of phosphatidylserine (PS) synthesis. The inhibition of the synthesis of this phospholipid could be partially reversed by IL-1. In Jurkat cells, IL-1 did not activate phosphodiesterases as demonstrated by the lack of change of inositol triphosphate and diacylglycerol levels as well as the lack of change in cytosolic Ca2+ concentration. Furthermore, IL-1 did not modify the intracellular level of cGMP and cAMP, suggesting that the observed rise of PS synthesis could play the role of mediator IL-1 action. As PS is a necessary cofactor for the activation of protein kinase C, our results suggest strongly that IL-1 modulate protein kinase C activity in the activated lymphocyte through its action on PS synthesis.


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