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The Journal of Immunology, Vol 141, Issue 9 3061-3066, Copyright © 1988 by American Association of Immunologists

ARTICLES

Natural cytotoxic cell-specific cytotoxic factor produced by IL-3- dependent basophilic/mast cells. Relationship to TNF

AL Richards, T Okuno, Y Takagaki and JY Djeu
Department of Medical Microbiology/Immunology, University of South Florida, Tampa 33612.

The murine IL-3-dependent mast cell line, PT18-A17, and the rat basophilic leukemia cell line, RBL-2H3, were found to mediate natural cytotoxic (NC) activity via the release of a soluble factor which specifically lysed NC-sensitive WEHI-164 but not NK-sensitive YAC-1 tumor cells. The release of this NC cell-specific cytotoxic factor was enhanced by triggering of both types of cells via IgE receptor bridging. This factor had activity on TNF-sensitive but not TNF- resistant cell lines and could be neutralized by two independently produced polyclonal anti-mouse TNF antisera. It was not neutralized by antibodies against mouse IFN-alpha/beta or IFN-gamma. Moreover, it was not neutralized by a monoclonal or a polyclonal anti-human TNF, demonstrating that the rodent TNF differed antigenically from human TNF. These results indicate that the cytotoxic factor released from a murine IL-3-dependent mast cell line and from a rat basophilic leukemia cell line is immunologically and functionally related to murine TNF.


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