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The Journal of Immunology, Vol 141, Issue 8 2749-2754, Copyright © 1988 by American Association of Immunologists

ARTICLES

Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells

F Oftung, AS Mustafa, TM Shinnick, RA Houghten, G Kvalheim, M Degre, KE Lundin and T Godal
Laboratory for Immunology, Norwegian Radium Hospital, Oslo.

A synthetic peptide approach has been used to identify the epitopes recognized by clonal and polyclonal human T cells reactive to the recombinant mycobacterial 65-kDa protein Ag. Three of the four epitopes identified were recognized as cross-reactive between Mycobacterium tuberculosis and Mycobacterium leprae, although their amino acid sequence in two of three cases was not identical. The peptide (231-245) defining an epitope recognized as specific to the M. tuberculosis complex contains two substitutions compared with the homologous M. leprae region of which one or both are critical to T cell recognition. The reactive T cell clones showed helper/inducer phenotype (CD4+, CD8- ), and secrete IL-2, granulocyte-macrophage-CSF, and IFN-gamma upon Ag stimulation. The same clones display cytotoxicity against macrophages pulsed with the relevant peptides or mycobacteria.


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