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The Journal of Immunology, Vol 141, Issue 5 1665-1669, Copyright © 1988 by American Association of Immunologists

ARTICLES

Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies

R Rothlein, M Czajkowski, MM O'Neill, SD Marlin, E Mainolfi and VJ Merluzzi
Department of Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT 06877.

The expression of intercellular adhesion molecule-1 (ICAM-1) on primary human fibroblasts, a human fibrosarcoma, chondrosarcoma, and adenocarcinoma cell line in response to IL-1, TNF-alpha, or IFN-gamma was studied using an ELISA with anti-ICAM-1 mAb. The induction of ICAM- 1 by these cytokines was neutralized by cytokine-specific antisera as well as some steroids and the glycosylation inhibitor, tunicamycin. Cyclohexamide up-regulated the expression of ICAM-1 on chondrosarcoma cells but had little or no effect on carcinoma cells. These data indicate different mechanisms in the regulation and expression of ICAM- 1 on the various cell types and provide some insight into the anti- inflammatory effects of some pharmacologic agents.


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