| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 141, Issue 4 1295-1301, Copyright © 1988 by American Association of Immunologists
ARTICLES |
KL Hartshorn, M Collamer, M Auerbach, JB Myers, N Pavlotsky and AI Tauber
William B. Castle Hematology Laboratory, Boston City Hospital, MA 02118.
Bacterial superinfection in influenza A virus-related illness may in part be explained by virus-induced neutrophil dysfunction. We here provide evidence that this effect is related to abnormal calcium metabolism of virus-infected cells. Neutrophils exposed to influenza virus for 0.5 h at 37 degrees C showed depressed O2- generation and release of radiolabeled arachidonic acid upon stimulation with FMLP. The peak cytosolic Ca2+ level achieved by virus-infected neutrophils after FMLP stimulation was significantly depressed as is efflux of 45Ca2+. This deficient Ca2+ mobilization could not be attributed to alterations of inositol phosphate production or Ca2+ influx in response to FMLP, both of which were unaffected by prior virus infection. Given these findings, the immediate effects of influenza virus on neutrophil Ca2+ metabolism were examined. The virus itself caused a rise in cytosolic Ca2+ and an efflux of 45Ca2+ without any corresponding 45Ca2+ influx. Total cell Ca2+ however was not depleted as measured by atomic absorption. Influenza virus, therefore, causes neutrophil activation leading to significant perturbations in Ca2+ metabolism and later to impaired mobilization of Ca2+ stores. This system offers a model for phagocyte deactivation and an opportunity to define control mechanisms of signal transduction.
This article has been cited by other articles:
|
|
 |
|
  M. Doss, M. R. White, T. Tecle, D. Gantz, E. C. Crouch, G. Jung, P. Ruchala, A. J. Waring, R. I. Lehrer, and K. L. Hartshorn Interactions of {alpha}-, {beta}-, and {theta}-Defensins with Influenza A Virus and Surfactant Protein D J. Immunol., June 15, 2009; 182(12): 7878 - 7887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, R. Oberley-Deegan, S. Wang, M. Nikrad, C. J. Funk, K. L. Hartshorn, and R. J. Mason Differentiated Human Alveolar Type II Cells Secrete Antiviral IL-29 (IFN-{lambda}1) in Response to Influenza A Infection J. Immunol., February 1, 2009; 182(3): 1296 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. White, P. Kingma, T. Tecle, N. Kacak, B. Linders, J. Heuser, E. Crouch, and K. Hartshorn Multimerization of Surfactant Protein D, but Not Its Collagen Domain, Is Required for Antiviral and Opsonic Activities Related to Influenza Virus J. Immunol., December 1, 2008; 181(11): 7936 - 7943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. White, T. Tecle, E. C. Crouch, and K. L. Hartshorn Impact of neutrophils on antiviral activity of human bronchoalveolar lavage fluid Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1293 - L1299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tecle, M. R. White, D. Gantz, E. C. Crouch, and K. L. Hartshorn Human Neutrophil Defensins Increase Neutrophil Uptake of Influenza A Virus and Bacteria and Modify Virus-Induced Respiratory Burst Responses J. Immunol., June 15, 2007; 178(12): 8046 - 8052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hartshorn, M. R. White, T. Tecle, U. Holmskov, and E. C. Crouch Innate Defense against Influenza A Virus: Activity of Human Neutrophil Defensins and Interactions of Defensins with Surfactant Protein D. J. Immunol., June 1, 2006; 176(11): 6962 - 6972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Meschi, E. C. Crouch, P. Skolnik, K. Yahya, U. Holmskov, R. Leth-Larsen, I. Tornoe, T. Tecle, M. R. White, and K. L. Hartshorn Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication J. Gen. Virol., November 1, 2005; 86(11): 3097 - 3107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. White, E. Crouch, J. Vesona, P. J. Tacken, J. J. Batenburg, R. Leth-Larsen, U. Holmskov, and K. L. Hartshorn Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L606 - L616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. White, E. Crouch, M. van Eijk, M. Hartshorn, L. Pemberton, I. Tornoe, U. Holmskov, and K. L. Hartshorn Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L831 - L840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Leth-Larsen, P. Garred, H. Jensenius, J. Meschi, K. Hartshorn, J. Madsen, I. Tornoe, H. O. Madsen, G. Sorensen, E. Crouch, et al. A Common Polymorphism in the SFTPD Gene Influences Assembly, Function, and Concentration of Surfactant Protein D J. Immunol., February 1, 2005; 174(3): 1532 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. LeVine, J. Elliott, J. A. Whitsett, A. Srikiatkhachorn, E. Crouch, N. DeSilva, and T. Korfhagen Surfactant Protein-D Enhances Phagocytosis and Pulmonary Clearance of Respiratory Syncytial Virus Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2): 193 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Eijk, M. R. White, J. J. Batenburg, A. B. Vaandrager, L. M. G. van Golde, H. P. Haagsman, and K. L. Hartshorn Interactions of Influenza A Virus with Sialic Acids Present on Porcine Surfactant Protein D Am. J. Respir. Cell Mol. Biol., June 1, 2004; 30(6): 871 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hartshorn, M. R. White, T. Mogues, T. Ligtenberg, E. Crouch, and U. Holmskov Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses Am J Physiol Lung Cell Mol Physiol, November 1, 2003; 285(5): L1066 - L1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Eijk, M. R. White, E. C. Crouch, J. J. Batenburg, A. B. Vaandrager, L. M. G. van Golde, H. P. Haagsman, and K. L. Hartshorn Porcine Pulmonary Collectins Show Distinct Interactions with Influenza A Viruses: Role of the N-Linked Oligosaccharides in the Carbohydrate Recognition Domain J. Immunol., August 1, 2003; 171(3): 1431 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Hartshorn, M. R. White, and E. C. Crouch Contributions of the N- and C-Terminal Domains of Surfactant Protein D to the Binding, Aggregation, and Phagocytic Uptake of Bacteria Infect. Immun., November 1, 2002; 70(11): 6129 - 6139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. ENGELICH, M. WHITE, and K. L. HARTSHORN Role of the respiratory burst in co-operative reduction in neutrophil survival by influenza A virus and Escherichia coli J. Med. Microbiol., June 1, 2002; 51(6): 484 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. LeVine, K. Hartshorn, J. Elliott, J. Whitsett, and T. Korfhagen Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L563 - L572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. LeVine, J. A. Whitsett, K. L. Hartshorn, E. C. Crouch, and T. R. Korfhagen Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo J. Immunol., November 15, 2001; 167(10): 5868 - 5873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Engelich, M. White, and K. L. Hartshorn Neutrophil survival is markedly reduced by incubation with influenza virus and Streptococcus pneumoniae: role of respiratory burst J. Leukoc. Biol., January 1, 2001; 69(1): 50 - 56. [Abstract] [Full Text]
|
|
|
|
|
|
K. L. Hartshorn, K. N. Sastry, D. Chang, M. R. White, and E. C. Crouch Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L90 - L98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Colamussi, M. R. White, E. Crouch, and K. L. Hartshorn Influenza A Virus Accelerates Neutrophil Apoptosis and Markedly Potentiates Apoptotic Effects of Bacteria Blood, April 1, 1999; 93(7): 2395 - 2403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dolan, K. Hartshorn, C. Andry, J. Tablante, G. Grillone, D. McAvoy, and C. Suntra In Vivo Correlation of Neutrophil Receptor Expression, Ischemia-Reperfusion Injury, and Selective 5-Lipoxygenase Inhibition in Guinea Pigs Arch Otolaryngol Head Neck Surg, December 1, 1998; 124(12): 1377 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hartshorn, E. Crouch, M. R. White, M. L. Colamussi, A. Kakkanatt, B. Tauber, V. Shepherd, and K. N. Sastry Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L958 - L969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Brown-Augsburger, K. Hartshorn, D. Chang, K. Rust, C. Fliszar, H. G. Welgus, and E. C. Crouch Site-directed Mutagenesis of Cys-15 and Cys-20 of Pulmonary Surfactant Protein D. EXPRESSION OF A TRIMERIC PROTEIN WITH ALTERED ANTI-VIRAL PROPERTIES J. Biol. Chem., June 7, 1996; 271(23): 13724 - 13730. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
