| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 141, Issue 4 1197-1201, Copyright © 1988 by American Association of Immunologists
ARTICLES |
JM Debets, CJ Van der Linden, IE Dieteren, JF Leeuwenberg and WA Buurman
Department of General Surgery, University of Limburg, Maastricht, The Netherlands.
In this study it was demonstrated that cross-linking of FcR on human monocytes induces the secretion of the cytotoxic and immunoregulatory cytokine TNF. Both soluble and insoluble immune complexes, solid-phase antibody and antibody-coated phagocytizable particles were used to cross-link FcR on monocytes. It was observed that monocytes secreted large amounts of TNF in each of these instances. Kinetic studies performed with soluble immune complexes showed that TNF was secreted very rapidly, e.g., within 2 h after addition of immune complexes to monocytes. These findings are relevant for the understanding of FcR- mediated immune responses by monocytes and macrophages, for example antibody-dependent cellular cytotoxicity and phagocytosis, and for disease states associated with circulating or tissue-fixed immune complexes.
This article has been cited by other articles:
|
|
 |
|
  J S Smolen, D Aletaha, and G Steiner Does damage cause inflammation? Revisiting the link between joint damage and inflammation Ann Rheum Dis, February 1, 2009; 68(2): 159 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Olazabal, N. B. Martin-Cofreces, M. Mittelbrunn, G. Martinez del Hoyo, B. Alarcon, and F. Sanchez-Madrid Activation Outcomes Induced in Naive CD8 T-Cells by Macrophages Primed via "Phagocytic" and Nonphagocytic Pathways Mol. Biol. Cell, February 1, 2008; 19(2): 701 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J S Smolen, G Steiner, and M Aringer Anti-cytokine therapy in systemic lupus erythematosus Lupus, March 1, 2005; 14(3): 189 - 191. [Abstract] [PDF]
|
|
|
|
|
|
M Aringer and J S Smolen Cytokine expression in lupus kidneys Lupus, January 1, 2005; 14(1): 13 - 18. [Abstract] [PDF]
|
|
|
|
|
|
M Aringer and J S Smolen Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus: a rationale for therapeutic intervention Lupus, May 1, 2004; 13(5): 344 - 347. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Garcia-Garcia, G. Sanchez-Mejorada, and C. Rosales Phosphatidylinositol 3-kinase and ERK are required for NF-{kappa}B activation but not for phagocytosis J. Leukoc. Biol., October 1, 2001; 70(4): 649 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. D. McGilvray, L. Serghides, A. Kapus, O. D. Rotstein, and K. C. Kain Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance Blood, November 1, 2000; 96(9): 3231 - 3240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Lidbury and S. Mahalingam Specific Ablation of Antiviral Gene Expression in Macrophages by Antibody-Dependent Enhancement of Ross River Virus Infection J. Virol., September 15, 2000; 74(18): 8376 - 8381. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. A. Nockher and J. E. Scherberich Expanded CD14+ CD16+ Monocyte Subpopulation in Patients with Acute and Chronic Infections Undergoing Hemodialysis Infect. Immun., June 1, 1998; 66(6): 2782 - 2790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yoshikawa, T. Sakihama, Y. Nakajima, and K. Tasaka Fcgamma RIII-Mediated Regulation of Hematopoiesis in Murine Bone Marrow Cells by Interleukin-3 and CD95 (Fas/Apo-1) Blood, September 1, 1997; 90(5): 1911 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. McDonald, K. R. Brunden, and G. E. Landreth Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia J. Neurosci., April 1, 1997; 17(7): 2284 - 2294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Kiener, B. M. Rankin, P. M. Davis, S. A. Yocum, G. A. Warr, and R. I. Grove Immune Complexes of LDL Induce Atherogenic Responses in Human Monocytic Cells Arterioscler Thromb Vasc Biol, July 1, 1995; 15(7): 990 - 999. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. K. Takayama, C. Miller, and G. Szabo Elevated Tumor Necrosis Factor{alpha} Production Concomitant to Elevated Prostaglandin E2 Production by Trauma Patients' Monocytes Arch Surg, January 1, 1990; 125(1): 29 - 35. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
