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The Journal of Immunology, Vol 141, Issue 2 499-503, Copyright © 1988 by American Association of Immunologists
ARTICLES |
MR Shalaby, T Espevik, GC Rice, AJ Ammann, IS Figari, GE Ranges and MA Palladino Jr
Department of Pharmacological Sciences, Genentech, Inc., South San Francisco, CA 94080.
The influence of recombinant human TNF-alpha and -beta (rHuTNF-alpha and -beta) in a human mixed lymphocyte reaction (MLR) was investigated. The addition of 1000 U/ml of either cytokine at the initiation of culture caused up to a sixfold increase in [3H]thymidine incorporation by responder cells. Furthermore, it was found that endogenous HuTNF- alpha is produced after allogeneic cell interaction and can be detected in the MLR supernatant within 1 h of culture initiation. The results also show that, in the absence of exogenous HuTNF-alpha, antibodies to rHuTNF-alpha can cause a significant inhibition of the MLR. These observations indicate the importance of TNF-alpha in allogeneic cell interaction and raise considerations for the use of antibodies, or other antagonists, to TNF-alpha as regulators of disease states associated with cell-mediated immune reactions.
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