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The Journal of Immunology, Vol 141, Issue 12 4224-4228, Copyright © 1988 by American Association of Immunologists

ARTICLES

IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors

M Ogata, H Lorberboum-Galski, D FitzGerald and I Pastan
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892.

IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulated spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag- activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.


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I Pastan and D FitzGerald
Recombinant toxins for cancer treatment
Science, November 22, 1991; 254(5035): 1173 - 1177.
[Abstract] [PDF]


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