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The Journal of Immunology, Vol 141, Issue 12 4129-4132, Copyright © 1988 by American Association of Immunologists

ARTICLES

Helper T lymphocytes which recognize the MHC class I alloantigens in vivo are CD4+CD8-1

PF Piguet
Department of Pathology, University of Geneva, Switzerland.

To determine the CD4 or CD8 phenotype of the Th lymphocyte which recognizes in vivo the MHC class I alloantigens, B10 recombinant mice were treated with anti-CD8 or anti-CD4 mAb and immunized with lymphoid cells from donors differing in the K or D region of the MHC. Alloantibodies were evaluated by a 51Cr-release assay or by indirect immunofluorescence. The production of IgG anti-Dd and anti-Kk alloantibodies was increased by the deletion of the CD8+ and absent in mice depleted of the CD4+ subset. These experiments indicate that the helper influence elicited by the recognition of a MHC class I alloantigen in vivo is due to cells of the CD4+CD8- phenotype.


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