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The Journal of Immunology, Vol 141, Issue 12 4083-4088, Copyright © 1988 by American Association of Immunologists

ARTICLES

Regulation of antigen-presentation-I. IFN-gamma induces antigen- presenting properties on B cells

CM Hawrylowicz and ER Unanue
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.

B cells require activation to efficiently present Ag to T cells. In agreement with this earlier observation we show that live, mitomycin C- treated B cells, but not B cells fixed in paraformaldehyde, stimulated the growth of allogeneic T cells in the primary MLR. However, if B cells were cultured with anti-Ig antibodies and IFN-gamma before fixation they acquired excellent T cell stimulatory activity. Neither reagent alone conferred this novel co-stimulatory function on the B cell surface. The activity induced by both stimuli was not attributed to an increase expression of class II-MHC molecules or IL-1. IL-2 or IL- 4, in combination with anti-Ig, also induced B cell stimulatory activity, but were less effective than IFN-gamma. TNF failed to stimulate B cells, but synergized with IFN-gamma in the induction of this activity. These studies therefore demonstrate an important role for lymphokines in modulating B cell Ag-presenting activity as well as the acquisition by B cells of a novel co-stimulatory surface activity.


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