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The Journal of Immunology, Vol 141, Issue 10 3512-3515, Copyright © 1988 by American Association of Immunologists

ARTICLES

Possible association between IL-2 receptors and class I HLA molecules on T cells

M Sharon, JR Gnarra, M Baniyash and WJ Leonard
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

In the process of evaluating murine hybridomas for an antibody to the beta-subunit of the IL-2R (p70) we identified an antibody that immunoprecipitated a 55- to 57-kDa complex from cross-linked lysates. We demonstrate that this complex is composed of IL-2 (15.5 kDa) cross- linked to the H chain of HLA class I (40 to 42 kDa), suggesting a molecular interaction between HLA class I molecules and IL-2R. Although the exact role of this association remains to be determined, the specific cross-linking of IL-2 to HLA class I Ag is intriguing in view of published claims for a role of HLA class I in OKT3-induced lymphocyte proliferation and in NK cell lytic activity.


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