The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sharon, M.
Right arrow Articles by Leonard, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sharon, M.
Right arrow Articles by Leonard, W. J.

The Journal of Immunology, Vol 141, Issue 10 3512-3515, Copyright © 1988 by American Association of Immunologists

ARTICLES

Possible association between IL-2 receptors and class I HLA molecules on T cells

M Sharon, JR Gnarra, M Baniyash and WJ Leonard
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

In the process of evaluating murine hybridomas for an antibody to the beta-subunit of the IL-2R (p70) we identified an antibody that immunoprecipitated a 55- to 57-kDa complex from cross-linked lysates. We demonstrate that this complex is composed of IL-2 (15.5 kDa) cross- linked to the H chain of HLA class I (40 to 42 kDa), suggesting a molecular interaction between HLA class I molecules and IL-2R. Although the exact role of this association remains to be determined, the specific cross-linking of IL-2 to HLA class I Ag is intriguing in view of published claims for a role of HLA class I in OKT3-induced lymphocyte proliferation and in NK cell lytic activity.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. G. Santos, S. J. Powis, and F. A. Arosa
Misfolding of Major Histocompatibility Complex Class I Molecules in Activated T Cells Allows cis-Interactions with Receptors and Signaling Molecules and Is Associated with Tyrosine Phosphorylation
J. Biol. Chem., December 17, 2004; 279(51): 53062 - 53070.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. S. Hahn, A. Guanzon, C. M. Rice, and C. S. Hahn
Class I MHC Molecule-Mediated Inhibition of Sindbis Virus Replication
J. Immunol., January 1, 1999; 162(1): 69 - 77.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Skov, M. Nielsen, S. Bregenholt, N. Odum, and M. H. Claesson
Activation of Stat-3 Is Involved in the Induction of Apoptosis After Ligation of Major Histocompatibility Complex Class I Molecules on Human Jurkat T Cells
Blood, May 15, 1998; 91(10): 3566 - 3573.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Shaw, L. Tilney, A. Musoke, and A. Teale
MHC class I molecules are an essential cell surface component involved in Theileria parva sporozoite binding to bovine lymphocytes
J. Cell Sci., January 4, 1995; 108(4): 1587 - 1596.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
T. A. Waldmann, I. H. Pastan, O. A. Gansow, and R. P. Junghans
The Multichain Interleukin-2 Receptor: A Target for Immunotherapy
Ann Intern Med, January 15, 1992; 116(2): 148 - 160.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1988 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1988 by The American Association of Immunologists, Inc. All rights reserved.