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The Journal of Immunology, Vol 141, Issue 10 3410-3415, Copyright © 1988 by American Association of Immunologists
ARTICLES |
K Kaushansky, VC Broudy, JM Harlan and JW Adamson
Division of Hematology, University of Washington, School of Medicine, Seattle 98195.
A number of cell types have been shown to elaborate hematopoietic growth factors in response to inflammatory mediators in vitro. To determine if this response occurs in vivo, we have administered levels of TNF-alpha and TNF-beta (lymphotoxin) found during an inflammatory reaction to mice. Using Northern blot analysis to detect tissue levels of hematopoietic growth factor-specific transcripts, and specific biologic and immunologic assays to detect the presence of colony- stimulating factors in the serum, we have found that TNF-alpha and TNF- beta induce the transcription and production of granulocyte-macrophage- CSF, macrophage-CSF, and IL-1. These findings provide an in vivo mechanism for the hematopoietic response to inflammation.
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