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The Journal of Immunology, Vol 141, Issue 10 3313-3317, Copyright © 1988 by American Association of Immunologists
ARTICLES |
J Puri and Y Factorovich
Department of Chemical Immunology, Weizmann Institute of Sciences, Rehovot, Israel.
The effect of eight microbial protease inhibitors on Ag-presentation to six different Ag-specific T cell clones was investigated. We found that these protease inhibitors can inhibit Ag presentation in a highly selective manner. This selectivity was evident with T cell clones specific to different Ag as well as with T cells specific to the same Ag but differing in their H-2 restriction. The inhibition was to due to cytotoxicity or effects through the TCR because none of the eight inhibitors inhibited IL-2-induced T cell proliferation, and because they did not inhibit Ag presentation by fixed APC or synthetic polypeptide. The conclusion after these data suggests that each specific antigenic fragment is produced by a unique set of proteases.
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